ArticleACS omega2018
Hexafluoroisopropanol-Mediated Domino Reaction for the Synthesis of Thiazolo-androstenones: Potent Anticancer Agents.
Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents.ACS omega · 2024Article
- Pyrazole: an emerging privileged scaffold in drug discovery.Future medicinal chemistry · 2023Review
- Domino/Cascade and Multicomponent Reactions for the Synthesis of Thiazole Derivatives.Current organic chemistry · 2022Article
- Synthesis of Chimeric Thiazolo-Nootkatone Derivatives as Potent Antimicrobial Agents.ChemMedChem · 2021Article
- Antimelanoma activities of chimeric thiazole-androstenone derivatives.Royal Society open science · 2021Article
- Benign Synthesis of Fused-thiazoles with Enone-based Natural Products and Drugs for Lead Discovery.New journal of chemistry = Nouveau journal de chimie · 2021Article
- Article
- Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistantMolecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A cascade reaction of thioamides with 6β-bromoandrostenedione in hexafluoroisopropanol formed substituted thiazolo-androstenones. This is a simple and mild protocol to synthesize novel molecules by using readily available reagents and substrates. Feasibility of the reaction has been rationalized by density functional theory calculations. Moreover, these compounds are potent growth inhibitors of colon, central nervous system, melanoma, ovarian, and renal cancer cell lines with 50% growth inhibition values as low as 1.04 μM.
Identifiers
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Registered trials
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