Evidence map›Paper›PMID 30613808›Full record

ArticleACS omega2018

Cationic Silver Nanoclusters as Potent Antimicrobials against Multidrug-Resistant Bacteria.

Zil-E Huma, Akash Gupta, Ibrahim Javed, Riddha Das, Syed Zajif Hussain, Shazia Mumtaz, Irshad Hussain, Vincent M Rotello

Abstract read
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Nanoparticles as Potential Novel Therapies for Urinary Tract Infections.Frontiers in cellular and infection microbiology · 2021
    Review
  12. Review
  13. Nanosilver Mitigates Biofilm Formation via FapC Amyloidosis Inhibition.Small (Weinheim an der Bergstrasse, Germany) · 2020
    Article
  14. Genotoxicity of Silver Nanoparticles.Nanomaterials (Basel, Switzerland) · 2020
    Review
  15. Review
  16. Ag Nanoparticles/α-AgScientific reports · 2019
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zil-E HumaDepartment of Chemistry & Chemical Engineering, SBA School of Science & Engineering (SBASSE), Lahore University of Management Science (LUMS), DHA, Lahore 54792, Pakistan.
Akash GuptaDepartment of Chemistry, University of Massachusetts (UMass) Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Ibrahim JavedDepartment of Chemistry & Chemical Engineering, SBA School of Science & Engineering (SBASSE), Lahore University of Management Science (LUMS), DHA, Lahore 54792, Pakistan.
Riddha DasDepartment of Chemistry, University of Massachusetts (UMass) Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Syed Zajif HussainDepartment of Chemistry & Chemical Engineering, SBA School of Science & Engineering (SBASSE), Lahore University of Management Science (LUMS), DHA, Lahore 54792, Pakistan.
Shazia MumtazDepartment of Chemistry & Chemical Engineering, SBA School of Science & Engineering (SBASSE), Lahore University of Management Science (LUMS), DHA, Lahore 54792, Pakistan.
Irshad HussainDepartment of Chemistry & Chemical Engineering, SBA School of Science & Engineering (SBASSE), Lahore University of Management Science (LUMS), DHA, Lahore 54792, Pakistan.
Vincent M RotelloDepartment of Chemistry, University of Massachusetts (UMass) Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.

Funding

Engineered Polymer Nanoemulsions for Treatment of Wound Biofilm InfectionsR01AI134770 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Robin Patel, VINCENT M. ROTELLO · 2018 to 2026
$3.5M
NIAID NIH HHS R01 AI134770
6 · The paper itself

Abstract

Bacterial multidrug resistance (MDR) is a serious healthcare issue caused by the long-term subtherapeutic clinical treatment of infectious diseases. Nanoscale engineering of metal nanoparticles has great potential to address this issue by tuning the nano-bio interface to target bacteria. Herein, we report the use of branched polyethylenimine-functionalized silver nanoclusters (bPEI-Ag NCs) to selectively kill MDR pathogenic bacteria by combining the antimicrobial activity of silver with the selective toxicity of bPEI toward bacteria. The minimum inhibitory concentration of bPEI-Ag NCs was determined against 12 uropathogenic MDR strains and found to be 10- to 15-fold lower than that of PEI and 2- to 3-fold lower than that of AgNO

Identifiers

PMID30613808
PMCPMC6312629

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.