ArticleScience advances2019
Peripheral nerve transfers change target muscle structure and function.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Experimental Testing of Bionic Peripheral Nerve and Muscle Interfaces: Animal Model Considerations.Frontiers in neuroscience · 2019Pooled it
- Sensory nerve-derived signaling coordinates oropharyngeal structural organization that supports suckling and vocalization in neonatal mice.Nature communications · 2026Article
- Implanted microelectrode arrays in reinnervated muscles allow separation of neural drives from transferred polyfunctional nerves.Nature biomedical engineering · 2026Article
- Reinnervation of Muscle Targets Enhances the Separability of Motor Unit Signals Following Peripheral Nerve Transfers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Application strategies of autologous and decellularized nerve grafts: Structural and functional recovery.Neural regeneration research · 2026Article
- Algorithm for Surgical Management of Symptomatic Hand and Digital Neuromas.Plastic and reconstructive surgery. Global open · 2026Article
- A myoneural actuator with engineered biophysics for implantable biohybrid systems.Nature communications · 2026Article
- Experimental Analysis and Modeling Study of Impedance Changes in Decellularized and Recellularized Peripheral Nerves.Bioengineering (Basel, Switzerland) · 2026Article
- A novel mouse model simulating C5 palsy after cervical surgery.Animal models and experimental medicine · 2026Article
- Acutely denervated muscle EVs reshape neuronal mitochondrial metabolism via retrograde signaling to rescue peripheral nerve injury.Cell reports. Medicine · 2026Article
- Article
- A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries.Nature communications · 2025Article
- Degenerated nerve grafts provide similar quality and outcome in reconstructing critical nerve defects as compared to fresh nerve grafts.Frontiers in cell and developmental biology · 2025Article
- Development of Biomaterials for Addressing Upper Extremity Peripheral Nerve Gaps.Journal of hand surgery global online · 2024Review
- Creation of a biological sensorimotor interface for bionic reconstruction.Nature communications · 2024Article
- Peripheral neural interfaces: Skeletal muscles are hyper-reinnervated according to the axonal capacity of the surgically rewired nerves.Science advances · 2024Article
- Volume loss during muscle reinnervation surgery is correlated with reduced CMAP amplitude but not reduced force output in a rat hindlimb model.Frontiers in physiology · 2024Article
- Nerve function restoration following targeted muscle reinnervation after varying delayed periods.Neural regeneration research · 2023Article
- Toward higher-performance bionic limbs for wider clinical use.Nature biomedical engineering · 2023Review
- LncRNA XLOC_015548 affects the proliferation and differentiation of myoblasts via the MAPK signaling pathway.Experimental biology and medicine (Maywood, N.J.) · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective nerve transfers surgically rewire motor neurons and are used in extremity reconstruction to restore muscle function or to facilitate intuitive prosthetic control. We investigated the neurophysiological effects of rewiring motor axons originating from spinal motor neuron pools into target muscles with lower innervation ratio in a rat model. Following reinnervation, the target muscle's force regenerated almost completely, with the motor unit population increasing to 116% in functional and 172% in histological assessments with subsequently smaller muscle units. Muscle fiber type populations transformed into the donor nerve's original muscles. We thus demonstrate that axons of alternative spinal origin can hyper-reinnervate target muscles without loss of muscle force regeneration, but with a donor-specific shift in muscle fiber type. These results explain the excellent clinical outcomes following nerve transfers in neuromuscular reconstruction. They indicate that reinnervated muscles can provide an accurate bioscreen to display neural information of lost body parts for high-fidelity prosthetic control.
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