ArticleScience advances2019
IDH3α regulates one-carbon metabolism in glioblastoma.
Open access · goldAbstract read
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Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
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Who cites it
53 citing papers in PubMed, 70 citations in OpenAlex.
- Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1-JUN/FOS Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Construction and validation of a folate metabolism-related gene signature for prognosis prediction, immune landscape characterization, and molecular subtyping in glioma.Cancer causes & control : CCC · 2026Article
- Mitochondrial Gene Signature Reveals Novel Diagnostic Biomarkers for Autism Spectrum Disorder.Molecular neurobiology · 2026Article
- Article
- Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targeting.Journal of translational medicine · 2026Review
- Single-cell RNA and DNA methylome profiling reveal liquid helium vitrification enhances porcine parthenogenetically activated blastocyst viability.BMC genomics · 2026Article
- Temporal Integration of Serum Proteomics, Metabolomics and MRI Tumor Volumetrics via Deep Learning Identifies Systemic Mediators of Glioblastoma Response to Chemoradiotherapy.Research square · 2026Article
- Noncanonical role of astrocytic mitochondrial Cx43: suppressing IDH3α to sustain glycolytic homeostasis against depression.Cell death & disease · 2025Article
- Integrating large-scale in vitro functional genomic screen and multi-omics data to identify novel breast cancer targets.Breast cancer research and treatment · 2025Article
- Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer.Acta pharmacologica Sinica · 2025Article
- FOXM1 requires IDH1 for late genes expression in mitotic cells.Histochemistry and cell biology · 2024Article
- Evolution of Molecular Biomarkers and Precision Molecular Therapeutic Strategies in Glioblastoma.Cancers · 2024Review
- Proteo-metabolomics and patient tumor slice experiments point to amino acid centrality for rewired mitochondria in fibrolamellar carcinoma.Cell reports. Medicine · 2024Article
- Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.Experimental and therapeutic medicine · 2023Article
- Redox Homeostasis and Beyond: The Role of Wild-Type Isocitrate Dehydrogenases for the Pathogenesis of Glioblastoma.Antioxidants & redox signaling · 2023Review
- Co-inhibition of glutaminolysis and one-carbon metabolism promotes ROS accumulation leading to enhancement of chemotherapeutic efficacy in anaplastic thyroid cancer.Cell death & disease · 2023Article
- Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions.Nature metabolism · 2023Article
- Glioblastoma with a primitive neuronal component: A case report.Oncology letters · 2023Article
- Review
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Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Jasmine L MayKen and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA.ORCID 0000-0002-7071-993X
Fotini M KouriKen and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA.
Lisa A HurleyKen and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA.ORCID 0000-0001-7889-4954
Juan LiuDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Serena Tommasini-GhelfiKen and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA.
Yanrong JiPreventive Medicine, Health and Biomedical Informatics, Feinberg School of Medicine, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-0134-664X
Peng GaoMetabolomics Core Facility of Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0002-9991-6064
Andrea E CalvertKen and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA.
Andrew LeeDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA.
Navdeep S ChandelDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60615, USA.ORCID 0000-0001-7208-3886
Ramana V DavuluriPreventive Medicine, Health and Biomedical Informatics, Feinberg School of Medicine, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.
Craig M HorbinskiDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jason W LocasaleDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-7766-3502
Alexander H SteghKen and Ruth Davee Department of Neurology, The Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA.ORCID 0000-0003-2395-7967
Northwestern University · USRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityDuke University · US
Funding
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8MTumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9MNorthwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0MSTINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Pouya Jamshidi · 2018 to 2026
$21.4MTR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6MProject 3: Spherical Nucleic Acids as Immunotherapeutic Agents for Prostate CancerU54CA199091 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2015 to 2019
$11.7MTheranostic Magnetic Nanostructures for the Molecular Imaging of CancerU54CA151880 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2010 to 2014
$11.5MCARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4MMitochondrial metabolism and ROS regulate cancerR35CA197532 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2016 to 2022
$6.3MDietary methionine and cancerR01CA193256 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W. · 2015 to 2023
$3.1MInformatics Platform for Mammalian Gene Regulation at Isoform-levelR01LM011297 · NLM · WISTAR INSTITUTE · PI DAVULURI, RAMANA V · 2013 to 2020
$2.4MNCATS NIH HHS UL1 TR001422NCI NIH HHS P30 CA014236NCI NIH HHS P30 CA060553NCI NIH HHS P50 CA221747NCI NIH HHS R01 CA193256NCI NIH HHS R01 CA208783NCI NIH HHS R35 CA197532NCI NIH HHS T32 CA009560NCI NIH HHS U54 CA151880NCI NIH HHS U54 CA199091NIGMS NIH HHS P41 GM108569NIGMS NIH HHS T32 GM008152NIH HHS S10 OD018164NINDS NIH HHS R01 NS102669NLM NIH HHS R01 LM011297
Abstract
Mutation or transcriptional up-regulation of isocitrate dehydrogenases 1 and 2 (
Indexed as
AnimalsBrain NeoplasmsCell Line, TumorCitric Acid CycleCytosolDNA MethylationFemaleGlioblastomaGlycine HydroxymethyltransferaseHEK293 CellsHeterograftsHumansIsocitrate DehydrogenaseMiceMice, SCIDOxidative PhosphorylationGlycine HydroxymethyltransferaseIDH3A protein, humanIsocitrate DehydrogenaseSHMT protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.