Evidence map›Paper›PMID 30613760›Full record

ArticleSociological science2018

Schools as Moderators of Genetic Associations with Life Course Attainments: Evidence from the WLS and Add Health.

Sam Trejo, Daniel W Belsky, Jason D Boardman, Jeremy Freese, Kathleen Mullan Harris, Pam Herd, Kamil Sicinski, Benjamin W Domingue

Abstract read
In one paragraph

Article in Sociological science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. The genetic lottery goes to school: Better schools compensate for the effects of students' genetic differences.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  6. Exploring the Fetal Origins Hypothesis Using Genetic Data.Social forces; a scientific medium of social study and interpretation · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sam TrejoStanford University.
Daniel W BelskyDuke University.
Jason D BoardmanUniversity of Colorado Boulder.
Jeremy FreeseStanford University.
Kathleen Mullan HarrisUniversity of North Carolina at Chapel Hill.
Pam HerdUniversity of Wisconsin-Madison.
Kamil SicinskiUniversity of Wisconsin-Madison.
Benjamin W DomingueStanford University.

Funding

Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
Statistical Data Enclave CoreP30AG017266 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Michal Engelman · 1999 to 2026
$17.0M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Network on Life Course Health Dynamics and Disparities in 21st Century America RenewalR24AG045061 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, Sarah A. Burgard · 2014 to 2026
$5.2M
University of Colorado Population CenterP2CHD066613 · NICHD · UNIVERSITY OF COLORADO · PI JANE A MENKEN · 2015 to 2026
$3.7M
Add Health: A Genotype and Phenotype Resource for the Global Scientific CommunityR01HD073342 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 2012 to 2016
$3.6M
A Longitudinal Resource for Genetic Research in Behavioral & Health SciencesR01AG041868 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI FREESE, JEREMY J, HAUSER, ROBERT M. · 2013 to 2017
$3.0M
Social Demographic Moderation of Genome Wide Associations for Body Mass IndexR01HD060726 · NICHD · UNIVERSITY OF COLORADO · PI BOARDMAN, JASON D, MCQUEEN, MATTHEW B · 2010 to 2014
$2.7M
NIA NIH HHS P30 AG017266NIA NIH HHS R01 AG041868NIA NIH HHS R24 AG045061NICHD NIH HHS P01 HD031921NICHD NIH HHS P2C HD050924NICHD NIH HHS P2C HD066613NICHD NIH HHS R01 HD060726NICHD NIH HHS R01 HD073342
6 · The paper itself

Abstract

Genetic variants identified in genome-wide association studies of educational attainment have been linked with a range of positive life course development outcomes. However, it remains unclear whether school environments may moderate these genetic associations. We analyze data from two biosocial surveys that contain both genetic data and follow students from secondary school through mid- to late life. We test if the magnitudes of the associations with educational and occupational attainments varied across the secondary schools that participants attended or with characteristics of those schools. Although we find little evidence that genetic associations with educational and occupational attainment varied across schools or with school characteristics, genetic associations with any postsecondary education and college completion were moderated by school-level socioeconomic status. Along similar lines, we observe substantial between-school variation in the average level of educational attainment students achieved for a fixed genotype. These findings emphasize the importance of social context in the interpretation of genetic associations. Specifically, our results suggest that though existing measures of individual genetic endowment have a linear relationship with years of schooling that is relatively consistent across school environments, school context is crucial in connecting an individual's genotype to his or her likelihood of crossing meaningful educational thresholds.

Indexed as

educational attainmentGxEpolygenic scoreschools

Identifiers

PMID30613760
PMCPMC6314676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.