Evidence map›Paper›PMID 30613436›Full record

ArticleJournal of nanomedicine & nanotechnology2018

Advances in delivery systems for doxorubicin.

Na Zhao, Martin C Woodle, A James Mixson

Abstract read
In one paragraph

Article in Journal of nanomedicine & nanotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Modular functionalization of cellular nanodiscs enables targeted delivery of chemotherapeutics into tumors.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Na ZhaoDepartment of Pathology, University Maryland School of Medicine, 10 S. Pine St., University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.
Martin C WoodleAparna Biosciences Corp, 9119 Gaither Rd., Gaithersburg, MD 20877, United States.
A James MixsonDepartment of Pathology, University Maryland School of Medicine, 10 S. Pine St., University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.

Funding

Ident. of Structural Features of HK Polyplexes for Imprv. siRNA Deliv. to TumorsR01CA136938 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI MIXSON, ARCHIBALD JAMES · 2009 to 2012
$1.2M
NCI NIH HHS R01 CA136938
6 · The paper itself

Abstract

Doxorubicin is a widely used chemotherapy agent. Despite its utility, several adverse side effects, especially its irreversible cardiotoxicity and reversible nephrotoxicity, have prompted the development of liposomal carriers, many of which are FDA approved. Antitumor efficacies of approved liposome-Dox preparations can equal or exceed that of conventional doxorubicin. Because these liposomes carriers accumulate in solid tumor tissues via an enhanced permeation and retention (EPR) effect, these carriers have an improved safety profile. Nevertheless, a significant problem with the current drug delivery preparations of doxorubicin is a lack of efficacy toward tumors that exhibit multidrug resistance. In this review, we consider the development of drug delivery systems for doxorubicin, which improve the therapeutic window (efficacy and safety) and which address limitations of the current FDA-approved doxorubicin formulations.

Indexed as

Doxorubicinintratumoralmultidrug resistancenanoparticlesystemic

Identifiers

PMID30613436
PMCPMC6319900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.