ArticleBMJ open diabetes research & care2018
Clinical characteristics and outcomes of symptomatic and asymptomatic hypoglycemia in hospitalized patients with diabetes.
Article in BMJ open diabetes research & care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Sex differences in glycemic outcomes: a systematic review and meta-analysis of diabetes treatments.BMJ open diabetes research & care · 2026Pooled it
- American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022Guideline
- The impact of nursing staff education on diabetes inpatient glucose management: a pilot cluster randomised controlled trial.BMC endocrine disorders · 2022Trial
- Development and validation of an interpretable machine learning model for predicting in-hospital hypoglycemia in adults with type 1 diabetes mellitus: a multicenter retrospective study.Frontiers in endocrinology · 2026Article
- Effects of continuous glucose monitoring in enhanced recovery after colorectal cancer patient surgery with type 2 diabetes (application of CGM in the ERAS process of CRC patient with diabetes).Frontiers in medicine · 2025Article
- Continuous Reduction of Hypoglycemia Incidence Post-Endoscopic Polypectomy Through Quality Control Circle Implementation.Journal of multidisciplinary healthcare · 2025Article
- 16. Diabetes Care in the Hospital: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- Use of Continuous Glucose Monitors Upon Hospital Discharge of People With Diabetes: Promise, Barriers, and Opportunity.Journal of diabetes science and technology · 2024Review
- 16. Diabetes Care in the Hospital: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
- Clinical characteristics and influencing factors of hypoglycemia in hospitalized patients with type 2 diabetes mellitus: A cross-sectional study.Nursing open · 2023Article
- Continuous Glucose Monitoring Within Hospital: A Scoping Review and Summary of Guidelines From the Joint British Diabetes Societies for Inpatient Care.Journal of diabetes science and technology · 2023Article
- Update on the management of diabetes in long-term care facilities.BMJ open diabetes research & care · 2022Review
- Sex differences in glycemic measures, complications, discharge disposition, and postdischarge emergency room visits and readmission among non-critically ill, hospitalized patients with diabetes.BMJ open diabetes research & care · 2022Observational
- Hypoglycemia symptoms are reduced in hospitalized patients with diabetes.Journal of diabetes and its complications · 2021Article
- Article
- Challenges and Strategies for Inpatient Diabetes Management in Older Adults.Diabetes spectrum : a publication of the American Diabetes Association · 2020Article
- Inpatient Hypoglycemia: The Challenge Remains.Journal of diabetes science and technology · 2020Review
- Effect of beta blocker use and type on hypoglycemia risk among hospitalized insulin requiring patients.Cardiovascular diabetology · 2019Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
importanceThe frequency and impact of asymptomatic hypoglycemia in hospitalized patients with diabetes is not known.
objectiveWe determined the clinical characteristics and hospital outcomes of general medicine and surgery patients with symptomatic and asymptomatic hypoglycemia. RESEARCH DESIGN AND
methodsProspective observational study in adult patients with diabetes and blood glucose (BG) <70 mg/dL. Participants were interviewed about signs and symptoms of hypoglycemia using a standardized questionnaire. Precipitating causes, demographics, insulin regimen, and complications data during admission was collected.
resultsAmong 250 patients with hypoglycemia, 112 (44.8%) patients were asymptomatic and 138 (55.2%) had symptomatic hypoglycemia. Patients with asymptomatic hypoglycemia were older (59±11 years vs 54.8±13 years, p=0.003), predominantly males (63% vs 48%, p=0.014), and had lower admission glycosylated hemoglobin (8.2%±2.6 % vs 9.1±2.9%, p=0.006) compared with symptomatic patients. Compared with symptomatic patients, those with asymptomatic hypoglycemia had higher mean BG during the episode (60.0±8 mg/dL vs 53.8±11 mg/dL, p<0.001). In multivariate analysis, male gender (OR 2.08, 95% CI 1.13 to 3.83, p=0.02) and age >65 years (OR 4.01, 95% CI 1.62 to 9.92, p=0.02) were independent predictors of asymptomatic hypoglycemia. There were no differences in clinical outcome, composite of hospital complications (27% vs 22%, p=0.41) or in-hospital length of stay (8 days (IQR 4-14) vs 7 days (IQR 5-15), p=0.92)) between groups.
conclusionsAsymptomatic hypoglycemia was common among insulin-treated patients with diabetes but was not associated with worse clinical outcome compared with patients with symptomatic hypoglycemia. Older age and male gender were independent risk factors for asymptomatic hypoglycemia.
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