Evidence map›Paper›PMID 30613389›Full record

ReviewF1000Research2018

Anergy into T regulatory cells: an integration of metabolic cues and epigenetic changes at the Foxp3 conserved non-coding sequence 2.

Milagros Silva Morales, Daniel Mueller

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in F1000Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Milagros Silva MoralesDivision of Rheumatic and Autoimmune Diseases, Center for Immunology, and the University of Minnesota Medical School, Minneapolis, USA.ORCID 0000-0002-0794-2362
Daniel MuellerDivision of Rheumatic and Autoimmune Diseases, Center for Immunology, and the University of Minnesota Medical School, Minneapolis, USA.ORCID 0000-0003-1621-0419
University of Minnesota Medical Center · US

Funding

Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JENKINS, MARC KEVIN · 1993 to 2023
$31.1M
TRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3M
NCI NIH HHS T32 CA009138NIAID NIH HHS P01 AI035296
6 · The paper itself

Abstract

Peripheral immune self-tolerance relies on protective mechanisms to control autoreactive T cells that escape deletion in the thymus. Suppression of autoreactive lymphocytes is necessary to avoid autoimmunity and immune cell-mediated damage of healthy tissues. An intriguing relationship has emerged between two mechanisms of peripheral tolerance-induction of anergy and Foxp3

Indexed as

Epigenesis, GeneticAnimalsAutoimmunityCD4-Positive T-LymphocytesClonal AnergyConserved SequenceDNA MethylationForkhead Transcription FactorsHumansSelf ToleranceT-Lymphocytes, RegulatoryForkhead Transcription FactorsFOXP3 protein, humanAnergyCNS2 methylationFoxp3Peripheral toleranceTreg differentiation

Identifiers

PMID30613389
PMCPMC6305231
OpenAlexW2903923507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.