Evidence map›Paper›PMID 30613351›Full record

ArticleOncotarget2018

SOX2 haploinsufficiency promotes impaired vision at advanced age.

Leire Moreno-Cugnon, Ander Anasagasti, Maitane Ezquerra-Inchausti, Ander Izeta, Pedro de la Villa, Javier Ruiz-Ederra, Ander Matheu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Analysis ofInternational journal of molecular sciences · 2025
    Article
  3. The Role of SOX Transcription Factors in Ageing and Age-Related Diseases.International journal of molecular sciences · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Leire Moreno-CugnonCellular Oncology Group, Biodonostia Health Research Institute, San Sebastián, Spain.
Ander AnasagastiSensorial Neurodegeneration Group, Biodonostia Health Research Institute, San Sebastián, Spain.
Maitane Ezquerra-InchaustiSensorial Neurodegeneration Group, Biodonostia Health Research Institute, San Sebastián, Spain.
Ander IzetaTissue Engineering Laboratory, Biodonostia Health Research Institute, San Sebastián, Spain.
Pedro de la VillaVisual Neurophysiology, IRYCIS, University of Alcala, Madrid, Spain.
Javier Ruiz-EderraSensorial Neurodegeneration Group, Biodonostia Health Research Institute, San Sebastián, Spain.
Ander MatheuCellular Oncology Group, Biodonostia Health Research Institute, San Sebastián, Spain.
Biogipuzkoa Health Research Institute · ESInstituto Ramón y Cajal de Investigación Sanitaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related vision loss has been associated with degeneration of the retina and decline in Müller glia cell activity. Sox2 is a critical transcription factor for the development and maintenance of the mammalian retina. Here we determined the role of Sox2 in retinal aging. We observed a decline in the number of Sox2-positive Müller, amacrine and ganglion cells with age. We also explored the impact of

Indexed as

aginghaploinsufficiencyretina stem cell progenitorsSox2vision loss

Identifiers

PMID30613351
PMCPMC6291181
OpenAlexW2902858879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.