Evidence map›Paper›PMID 30613305›Full record

ArticleTheranostics2018

Therapeutic Fluorescent Hybrid Nanoparticles for Traceable Delivery of Glucocorticoids to Inflammatory Sites.

Joanna Napp, M Andrea Markus, Joachim G Heck, Christian Dullin, Wiebke Möbius, Dimitris Gorpas, Claus Feldmann, Frauke Alves

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  3. Review
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  7. Article
  8. Article
  9. Nanotechnology-Assisted Cell Tracking.Nanomaterials (Basel, Switzerland) · 2022
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Frontiers in bioengineering and biotechnology · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Joanna NappInstitute of Diagnostic and Interventional Radiology, University Medicine Goettingen, Goettingen, Germany.
M Andrea MarkusTranslational Molecular Imaging, Max-Planck Institute for Experimental Medicine, Goettingen, Germany.
Joachim G HeckInstitute of Inorganic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Christian DullinInstitute of Diagnostic and Interventional Radiology, University Medicine Goettingen, Goettingen, Germany.
Wiebke MöbiusDepartment of Neurogenetics, Max-Planck Institute for Experimental Medicine, Goettingen, Germany.
Dimitris GorpasInstitute of Biological and Medical Imaging, Helmholtz Zentrum Munich, Germany and Chair of Biological Imaging, Technical University of Munich, Germany.
Claus FeldmannInstitute of Inorganic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Frauke AlvesInstitute of Diagnostic and Interventional Radiology, University Medicine Goettingen, Goettingen, Germany.
Karlsruhe Institute of Technology · DEMax Planck Institute of Experimental Medicine · DEElettra-Sincrotrone Trieste S.C.p.A. · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of inflammatory disorders with glucocorticoids (GCs) is often accompanied by severe adverse effects. Application of GCs via nanoparticles (NPs), especially those using simple formulations, could possibly improve their delivery to sites of inflammation and therefore their efficacy, minimising the required dose and thus reducing side effects. Here, we present the evaluation of NPs composed of GC betamethasone phosphate (BMP) and the fluorescent dye DY-647 (BMP-IOH-NPs) for improved treatment of inflammation with simultaneous

Indexed as

Optical ImagingAnimalsAnti-Inflammatory AgentsBetamethasoneDisease Models, AnimalDrug CarriersDrug MonitoringExtremitiesFluorescent DyesGlucocorticoidsHypersensitivityInterleukin-6MacrophagesMiceMicroscopy, ElectronNanoparticlesAnti-Inflammatory AgentsBetamethasonebetamethasone sodium phosphateDrug CarriersFluorescent DyesGlucocorticoidsInterleukin-6hybrid nanoparticlesinflammatory diseasein vivo imagingmonitoring glucocorticoid deliverynanoparticle-based therapy

Identifiers

PMID30613305
PMCPMC6299685
OpenAlexW2904866372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.