Evidence map›Paper›PMID 30613140›Full record

Observational studyInternational journal of chronic obstructive pulmonary disease

Differences in health care outcomes between postdischarge COPD patients treated with inhaled corticosteroid/long-acting β

Eric T Wittbrodt, Lauren A Millette, Kristin A Evans, Machaon Bonafede, Joseph Tkacz, Gary T Ferguson

Open access · goldAbstract readComparative StudyObservational Study
In one paragraph

Observational study in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Eric T WittbrodtMedical Affairs, AstraZeneca, Wilmington, DE, USA, eric.wittbrodt@astrazeneca.com.
Lauren A MilletteMedical Affairs, AstraZeneca, Wilmington, DE, USA, eric.wittbrodt@astrazeneca.com.
Kristin A EvansLife Sciences, Value-Based Care, IBM Watson Health, Cambridge, MA, USA.
Machaon BonafedeLife Sciences, Value-Based Care, IBM Watson Health, Cambridge, MA, USA.
Joseph TkaczLife Sciences, Value-Based Care, IBM Watson Health, Cambridge, MA, USA.
Gary T FergusonPulmonary Research Institute of Southeast Michigan, Farmington Hills, MI, USA.
IBM (United States) · USAstraZeneca (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to examine real-world differences in health care resource use (HRU) and costs among COPD patients in the USA treated with a dry powder inhaler (DPI) or pressurized metered-dose inhaler (pMDI) following a COPD-related hospitalization.

methodsThis retrospective analysis used the Truven MarketScan

resultsThe sample included 1,960 DPI and 1,086 pMDI ICS/LABA patients. During the preindex period, pMDI patients were significantly more likely to be prescribed a short-acting β-agonist, experienced more COPD exacerbation-related hospital days, and had a greater number of pulmonologist visits compared to DPI patients (

conclusionDespite greater COPD-related HRU and costs preceding index hospitalization, US patients using a pMDI after hospital discharge incurred significantly lower all-cause and COPD-related health care costs compared with those using a DPI, in addition to a decreased likelihood of a COPD exacerbation-related hospital readmission. Results suggest that inhaler device type may influence COPD outcomes and that COPD patients may derive greater clinical benefit from treatment delivered via pMDI vs DPI.

Indexed as

Dry Powder InhalersMetered Dose InhalersPatient DischargeAdministration, InhalationAdrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsAdultAgedClinical Decision-MakingCost-Benefit AnalysisDatabases, FactualDisease ProgressionDrug CombinationsDrug CostsFemaleHospital CostsAdrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsDrug CombinationsCOPDcostsinhaled corticosteroidinhalerlong-acting β2-agonistutilization

Identifiers

PMID30613140
PMCPMC6307496
OpenAlexW2906467854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.