Evidence map›Paper›PMID 30612588›Full record

ArticleArthritis research & therapy2019

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis.

Mark R Tanner, Michael W Pennington, Satendra S Chauhan, Teresina Laragione, Pércio S Gulko, Christine Beeton

Open access · goldAbstract read
In one paragraph

Article in Arthritis research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. CaInternational journal of molecular sciences · 2023
    Review
  6. A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Modulation of Lymphocyte Potassium Channel KACS pharmacology & translational science · 2020
    Article
  12. Article
  13. Article
  14. Review
  15. Bioinformatics Analysis and Identification of Genes and Molecular Pathways Involved in Synovial Inflammation in Rheumatoid Arthritis.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Mark R TannerDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Michael W PenningtonPeptides International, Inc., Louisville, KY, USA.
Satendra S ChauhanPeptides International, Inc., Louisville, KY, USA.
Teresina LaragioneDivision of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pércio S GulkoDivision of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christine BeetonDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA. beeton@bcm.edu.ORCID 0000-0002-2500-5874
Baylor College of Medicine · USIcahn School of Medicine at Mount Sinai · USPeptides International (United States) · USRiverview Psychiatric Center · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
UM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5M
Consortium for Broad Based Disease Phenotyping of Knockout MiceU54HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L., PAYLOR, RICHARD E · 2011 to 2015
$17.0M
Molecular Physiology of the Cardiovascular SystemT32HL007676 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L · 1989 to 2020
$7.9M
Immunology Scientist Training ProgramT32AI053831 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI CORRY, DAVID B · 2003 to 2018
$4.2M
Training Program in Translational Biology and Molecular MedicineT32GM088129 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ROONEY, CLIONA M., VAN DEN VEYVER, IGNATIA B · 2010 to 2019
$3.0M
Magnesium and Arthritis PathogenesisR01AR073165 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GULKO, PERCIO S · 2019 to 2023
$1.8M
New Peptides for the Treatment of Multiple SclerosisR01NS073712 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI BEETON, CHRISTINE · 2011 to 2015
$1.8M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Regulation of cellular interactions by potassium channels in RAF31AR069960 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI TANNER, MARK R · 2016 to 2017
$76k
ARTHFN 6483NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NHGRI NIH HHS U54 HG006348NHGRI NIH HHS UM1 HG006348NHLBI NIH HHS T32 HL007676NIAID NIH HHS T32 AI053831NIAMS NIH HHS F31 AR069960NIAMS NIH HHS R01 AR073165NIGMS NIH HHS T32 GM088129NINDS NIH HHS R01 NS073712
6 · The paper itself

Abstract

backgroundFibroblast-like synoviocytes (FLS) and CCR7

methodsWe used in vitro functional assays to assess the effects of selective KCa1.1 and Kv1.3 channel inhibitors on the interactions of FLS isolated from rats with collagen-induced arthritis (CIA) with syngeneic T

resultsWe show that the interactions of FLS from rats with CIA and of rat T

conclusionsOur results demonstrate the importance of KCa1.1 and Kv1.3 in regulating FLS and T

Indexed as

AnimalsArthritis, ExperimentalArthritis, RheumatoidCells, CulturedFemaleFibroblastsHEK293 CellsHumansKv1.3 Potassium ChannelLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsRatsRats, Inbred LewSynoviocytesT-LymphocytesKcnma1 protein, ratKv1.3 Potassium ChannelLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsAutoimmunityCell interactionsDual therapyImmunomodulationSynovial fibroblast

Identifiers

PMID30612588
PMCPMC6322314
OpenAlexW2907105894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.