ArticleBiological research2019
Isolation of dihydrobenzofuran derivatives from ethnomedicinal species Polygonum barbatum as anticancer compounds.
Article in Biological research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 80 citations in OpenAlex.
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- Novel transition metal-free synthetic protocols toward the construction of 2,3-dihydrobenzofurans: a recent update.Frontiers in chemistry · 2024Review
- Polygonum barbatum extract reduces colorectal cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition via YAP and β-catenin pathway regulation.Scientific reports · 2023Article
- Antidiabetic, Antihyperlipidemic, and Antioxidant Evaluation of Phytosteroids fromPlants (Basel, Switzerland) · 2023Article
- Cytotoxic Activity of Wild Plant and Callus Extracts ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Anticancer therapeutic potential of benzofuran scaffolds.RSC advances · 2023Review
- New Succinimide-Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies.Molecules (Basel, Switzerland) · 2023Article
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- Phytochemistry, anti-diabetic and antioxidant potentials of Allium consanguineum Kunth.BMC complementary medicine and therapies · 2022Article
- α-Glucosidase, α-Amylase and Antioxidant Evaluations of Isolated Bioactives from Wild Strawberry.Molecules (Basel, Switzerland) · 2022Article
- 3-(((1Molecules (Basel, Switzerland) · 2022Article
- Succinimide Derivatives as Antioxidant Anticholinesterases, Anti-Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Antioxidant Molecules Isolated from Edible Prostrate Knotweed: Rational Derivatization to Produce More Potent Molecules.Oxidative medicine and cellular longevity · 2022Article
- Crude extract and isolated bioactive compounds from Notholirion thomsonianum (Royale) Stapf as multitargets antidiabetic agents: in-vitro and molecular docking approaches.BMC complementary medicine and therapies · 2021Article
- An Update on Phytochemicals and Pharmacological Activities of the GenusMolecules (Basel, Switzerland) · 2021Review
- Article
- Evaluation of Phytochemicals and Bioactive Properties in Mangrove AssociateFrontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEthnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of this family have been reported with anticancer potentials. This study was designed to isolate anticancer compounds from ethnomedicinally important species Polygonum barbatum.
methodsThe column chromatography was used for the isolation of compounds from the solvent fraction of P. barbatum. The characterization of isolated compounds was performed by various spectroscopic techniques like UV, IR, mass spectrometry and 1D-2D NMR spectroscopy. Keeping in view the ethnomedicinal importance of the family, genus and species of P. barbatum, the isolated compounds (1-3) were screened for anticancer potentials against oral cancer (CAL-27) and lungs cancer (NCI H460) cell lines using MTT assay. Active compound was further investigated for apoptosis by using morphological changes and flow cytometry analysis. In vivo anti-angiogenic study of the isolated compounds was also carried using chorioallantoic membrane assay. Docking studies were carried out to explore the mechanism of anticancer activity.
resultsThree dihydrobenzofuran derivatives (1-3) have been isolated from the ethyl acetate fraction of P. barbatum. The structures of isolated compounds were elucidated as methyl (2S,3S)-2-(3,4-dimethoxyphenyl)-4-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzo-furan-3-carboxylate (1), (E)-3-((2S,3S)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-(methoxy carbonyl)-2,3-dihydrobenzofuran-4-yl)acrylic acid (2) and (2S,3S)-4-((E)-2-carboxyvinyl)-2-(3,4-dimethoxyphenyl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylic acid (3). The compound 1 was found to be more potent with IC
conclusionBased on its overwhelming potency against the tested cell lines and in angiogenesis assay, compound 1 can be further evaluated mechanistically and can be developed as anticancer drug candidate.
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