Evidence map›Paper›PMID 30612568›Full record

Trial reportBMC cancer2019

Decreased mean platelet volume predicts poor prognosis in metastatic colorectal cancer patients treated with first-line chemotherapy: results from mCRC biomarker study.

Jinjia Chang, Guangyi Lin, Min Ye, Duo Tong, Jing Zhao, Dan Zhu, Qihe Yu, Wen Zhang, Wenhua Li

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03532711 (A Study to Characterize and Evaluate Biomarkers of Chemotherapy in Patients With Metastatic Colorectal Cancer In The First-line Setting), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03532711 completednot on this map

A Study to Characterize and Evaluate Biomarkers of Chemotherapy in Patients With Metastatic Colorectal Cancer In The First-line Setting

TypeobservationalSponsorFudan UniversityRan2012 to 2016Enrolled264ConditionsMetastatic Colorectal Cancer, Chemotherapy Effect, BiomarkerArmsfluorouracil
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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  7. Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jinjia ChangDepartment of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, People's Republic of China.ORCID http://orcid.org/0000-0002-9105-8691
Guangyi LinShanghai medical college, Fudan University, Shanghai, 200032, China.
Min YeDepartment of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, 200032, China.
Duo TongDepartment of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, People's Republic of China.
Jing ZhaoDepartment of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, People's Republic of China.
Dan ZhuDepartment of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, People's Republic of China.
Qihe YuDepartment of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, People's Republic of China.
Wen ZhangDepartment of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, People's Republic of China.
Wenhua LiDepartment of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai, People's Republic of China. whliiris@hotmail.com.
Shanghai Medical College of Fudan University · CNFudan University Shanghai Cancer Center · CN

Funding

National Outstanding Youth Foundation of China NSFC81602081
6 · The paper itself

Abstract

backgroundMetastatic colorectal cancer (mCRC) is a major cause of death of malignant tumor and the valuable prognostic biomarker for chemotherapy is crucial in decreasing mortality. Previous studies have proved the prognostic value of the mean platelet volume (MPV) in survival of primary operable CRC patients. However, the prognostic impact of MPV in mCRC is still unclear. In this study, we aimed to clarify the prognostic role of MPV in mCRC undergoing standard first-line chemotherapy.

methodsFrom January 2012 to December 2016, we conducted a retrospective clinical study included 264 mCRC patients (NCT03532711). All the enrolled patients received the standard oxaliplatin-based or irinotecan-based chemotherapy. The association between the baseline MPV and clinicopathological features were examined.

resultsUnivariate analysis revealed that decreased MPV, the platelet counts (PLT), platelet-to-lymphocyte ratio (PLR) and the platelet crit (PCT) were significantly associated with inferior overall survival (OS) (p < 0.05). On multivariate analysis, elevated PLR was significant prognostic factors for OS, with hazard ratios of (HR:1.006, 95% CI:1.001-1.011, p = 0.01) while MPV was not, respectively (p < 0.05).

conclusionsOur study demonstrated that the baseline MPV level may act as a predictive factor for survival in mCRC patients undergoing standard chemotherapy.

trial registrationThis study was retrospectively registered in date May the 20th 2018. The registration number (TRN) of this study was NCT03532711 .

Indexed as

PrognosisAgedBiomarkers, TumorBlood PlateletsColorectal NeoplasmsFemaleHumansLymphocyte CountLymphocytesMaleMean Platelet VolumeMiddle AgedNeoplasm MetastasisPlatelet CountProgression-Free SurvivalBiomarkers, TumorBiomarkerChemotherapyMetastatic colorectal cancerMPV

Identifiers

PMID30612568
PMCPMC6322328
OpenAlexW2908270033

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.