SynthesisBMC cancer2019
Total hysterectomy versus uterine evacuation for preventing post-molar gestational trophoblastic neoplasia in patients who are at least 40 years old: a systematic review and meta-analysis.
Synthesis in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Unintended consequences of vaginal misoprostol use in a patient with hydatidiform mole: A case report.Medicine · 2026Article
- The value of hysterectomy in the management of gestational trophoblastic neoplasia: a retrospective analysis.World journal of surgical oncology · 2026Article
- Initial Treatment and Outcomes of Complete Hydatidiform Mole in Women 40 Years or Older: A Multicenter Cohort Study.Cancers · 2025Article
- Gestational Trophoblastic Disease: Diagnostic and Therapeutic Updates in Light of Recent Evidence: A Literature Review.Medicina (Kaunas, Lithuania) · 2025Review
- Diagnosis and management of gestational trophoblastic disease: 2025 update.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- Diagnosis and Surgical Treatment of Hydatidiform Mole.Diagnostics (Basel, Switzerland) · 2025Review
- Molar Pregnancy: Early Diagnosis, Clinical Management, and the Role of Referral Centers.Diagnostics (Basel, Switzerland) · 2025Review
- Gestational trophoblastic neoplasm: Patient outcomes and clinical pearls from a multidisciplinary referral center.Gynecologic oncology · 2025Article
- Factors influencing serum hCG negativization timing in gestational trophoblastic neoplasia.American journal of cancer research · 2025Article
- Clinical Features of Gestational Trophoblastic Disease in Aged Women in South Vietnam.Yonsei medical journal · 2023Article
- Gestational trophoblastic neoplasm in a patient with end-stage renal failure (ESRF): the challenges and lessons learnt.BMJ case reports · 2022Article
- Diagnosis and management of gestational trophoblastic disease: 2021 update.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021Article
- Role of Hysterectomy in Gestational Trophoblastic Neoplasia.Indian journal of surgical oncology · 2021Article
- Perimenopausal giant hydatidiform mole complicated with preeclampsia and hyperthyroidism: A case report and literature review.Open medicine (Warsaw, Poland) · 2021Article
- Invasive Mole Resulting in Uterine Rupture: A Case Report.Frontiers in surgery · 2021Article
- The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study.Nagoya journal of medical science · 2020Observational
- A comparison of the clinical features of molar pregnancy in adolescents and adults.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical value of total hysterectomy for patients with hydatidiform mole (HM) being at least 40 years old remains highly controversial. Since the practice of hysterectomy has been applied globally for decades, there is an urgent need to perform a systematic review to assess its risks and benefits.
methodsSix electronic databases, including four English databases and one Chinese database, were searched from the inception of each database till October 6th 2017. Studies were included if they: 1) were human studies, 2) explicitly indicated exposure to hysterectomy, 3) explicitly indicated control to uterine evacuation, 4) explicitly indicated the participants were older patients with HM being at least 40 years in age, 5) compared the outcome of interest as the incidence of post-molar GTN. Two authors independently conducted the literature search, study selection, data extraction. Pooled odds ratios were analyzed using Review Manager 5.3.
resultsThe overall pooled effect size of total hysterectomy had a significant advantage in preventing post-molar gestational trophoblastic neoplasia over uterine evacuation with an OR of 0.19 (95% CI, 0.08-0.48; P = 0.0004) and a low heterogeneity (I
conclusionsTotal hysterectomy, as compared to uterine evacuation, is a better therapeutic method for patients with HM being at least 40 years old unless fertility is still desired.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.