Evidence map›Paper›PMID 30612334›Full record

ArticleMolecular neurobiology2019

In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrP

Zerui Wang, Jue Yuan, Pingping Shen, Romany Abskharon, Yue Lang, Johnny Dang, Alise Adornato, Ling Xu, Jiafeng Chen, Jiachun Feng and 11 more

Erratum issuedAbstract read
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Zerui WangDepartment of Neurology, The First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Jue YuanDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Pingping ShenDepartment of Neurology, The First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Romany AbskharonCenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.
Yue LangDepartment of Neurology, The First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Johnny DangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Alise AdornatoDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Ling XuDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Jiafeng ChenDepartment of Neurology, The First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Jiachun FengDepartment of Neurology, The First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China.
Mohammed MoudjouVirologie Immunologie Moléculaires, INRA, Jouy-en-Josas, France.
Tetsuyuki KitamotoCenter for Prion Diseases, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Hyoung-Gon LeeDepartment of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, TX, 78249, USA.
Yong-Sun KimDepartment of Microbiology, College of Medicine, Hallym University, Chuncheon, Gangwon-do, 24252, Republic of Korea.
Jan LangeveldWageningen BioVeterinary Research, Houtribweg 39, Lelystad, the Netherlands.
Brian ApplebyDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Jiyan MaCenter for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, 49503, USA.
Qingzhong KongDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Robert B PetersenDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA. robert.petersen@cmich.edu.
Wen-Quan ZouDepartment of Neurology, The First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China. wxz6@case.edu.ORCID http://orcid.org/0000-0001-8062-0370
Li CuiDepartment of Neurology, The First Hospital of Jilin University, Changchun, Jilin Province, People's Republic of China. chuili1967@126.com.

Funding

Role of skin prions in disease transmission and diagnostic testing of human prion diseaseR01NS109532 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2018 to 2022
$2.9M
Pathogenicity of prion protein aggregates from uninfected cells and brainsR01NS062787 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI ZOU, WEN-QUAN · 2009 to 2013
$1.4M
Cervid to human prion transmissionR01NS088604 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2015 to 2018
$1.4M
Generating iPSC-derived Neurons to Explore Formation & Inhibition of Human PrionsR21NS087588 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN, TESAR, PAUL JOSEPH · 2014 to 2015
$436k
NIH HHS NS087588NINDS NIH HHS R01 NS062787NINDS NIH HHS R01 NS088604NINDS NIH HHS R01 NS109532NINDS NIH HHS R21 NS087588
6 · The paper itself

Abstract

Both sporadic variably protease-sensitive prionopathy (VPSPr) and familial Creutzfeldt-Jakob disease linked to the prion protein (PrP) V180I mutation (fCJD

Indexed as

AnimalsBrainCreutzfeldt-Jakob SyndromeGlycosylationHumansMice, TransgenicMutationPeptide HydrolasesPrion ProteinsProtein FoldingSubstrate SpecificityPeptide HydrolasesPrion ProteinsHumanized transgenic micePolymorphismPrionPrion diseaseReal-time quaking-induced conversion (RT-QuIC)Serial protein misfolding cyclic amplification (sPMCA)Variably protease-sensitive prionopathy (VPSPr)

Identifiers

PMID30612334
PMCPMC6614145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.