ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2018
Methanogenesis on Early Stages of Life: Ancient but Not Primordial.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Benthic Microbial Community Features and Environmental Correlates in the Northwest Pacific Polymetallic Nodule Field, with Comparative Analysis Across the Pacific.Microorganisms · 2026Article
- Navigating the Complex Terrain of Methane Synthesis: Multienzyme Control Points and Data-Driven Strategies.ACS omega · 2025Article
- Metabolic and physiological adaptations of microalgal growth-promoting bacterium Azospirillum brasilense growing under biogas atmosphere: a microarray-based transcriptome analysis.Archives of microbiology · 2024Article
- Unraveling the phylogenomic diversity of Methanomassiliicoccales and implications for mitigating ruminant methane emissions.Genome biology · 2024Article
- Novel complete methanogenic pathways in longitudinal genomic study of monogastric age-associated archaea.Animal microbiome · 2023Article
- Holocene life and microbiome profiling in ancient tropical Lake Chalco, Mexico.Scientific reports · 2021Article
- Brockarchaeota, a novel archaeal phylum with unique and versatile carbon cycling pathways.Nature communications · 2021Article
- An archaeal origin of the Wood-Ljungdahl HNature microbiology · 2019Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Of the six known autotrophic pathways, the Wood-Ljungdahl pathway (WL) is the only one present in both the acetate producing Bacteria (homoacetogens) and the methane producing Archaea (hydrogenotrophic methanogens), and it has been suggested that WL is one of the oldest metabolic pathways. However, only the so-called carbonyl branch is shared by Archaea and Bacteria, while the methyl branch is different, both in the number of reactions and enzymes, which are not homologous among them. In this work we show that some parts of the methyl branch of archaeal Wood-Ljungdahl pathway (MBWL) are present in bacteria as well as in non-methanogen archaea, although the tangled evolutionary history of MBWL cannot be traced back to the Last Common Ancestor. We have also analyzed the different variants of methanogenesis (hydrogenotrophic, acetoclastic and methylotrophic pathways), and concluded that each of these pathways, and every different enzyme or subunit (in the case of multimeric enzymes), has their own intricate evolutionary history. Our study supports the scenario of hydrogenotrophic methanogenesis being older than the other variants, albeit not old enough to be present in the last archaeal common ancestor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.