Evidence map›Paper›PMID 30612237›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Relationship between social support, quality of life, and Th2 cytokines in a biobehavioral cancer survivorship trial.

Kathryn Osann, Justin Wilford, Lari Wenzel, Susie Hsieh, Jo A Tucker, Aditi Wahi, Bradley J Monk, Edward L Nelson

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06340906 (Electroacupuncture in Symptom Management After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06340906 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Electroacupuncture in Symptom Management After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

TypeinterventionalSponsorUniversity of California, IrvineRan2024 to 2026Enrolled20ConditionsCancerArmsElectroacupuncture
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kathryn OsannDepartment of Medicine, Division of Hematology/Oncology, University of California Irvine, 204 Sprague Hall, Irvine, CA, 92697, USA. kosann@uci.edu.
Justin WilfordProgram in Public Health, University of California Irvine, Irvine, CA, USA.
Lari WenzelChao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA.
Susie HsiehChao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA.
Jo A TuckerDepartment of Medicine, Division of Hematology/Oncology, University of California Irvine, 204 Sprague Hall, Irvine, CA, 92697, USA.
Aditi WahiChao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA.
Bradley J MonkSchool of Medicine, St. Joseph's Hospital and Medical Center, Creighton University, Phoenix, AZ, USA.
Edward L NelsonDepartment of Medicine, Division of Hematology/Oncology, University of California Irvine, 204 Sprague Hall, Irvine, CA, 92697, USA.
University of California, Irvine · USSt. Joseph's Hospital and Medical Center · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Stress, Immunity & Cervical Cancer: Biobehavioral Outcomes of a Randomized TrialR01CA118136 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI WENZEL, LARI · 2007 to 2011
$2.3M
CSUF and UCI-CFCCC Partnership for Cancer Health Disparities Research (2 of 2)P20CA174188 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUBBELL, FLOYD ALLAN · 2012 to 2015
$583k
NCATS NIH HHS UL1 TR001414NCI NIH HHS P20 CA174188NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA118136NCI NIH HHS RO1 CA118136-01
6 · The paper itself

Abstract

objectiveBenefits of social support (SS) during cancer survivorship are complex. This study examines change in SS over time in cervical cancer (CXCA) survivors who have completed definitive treatment and how changing SS impacts quality of life (QOL) and T-helper type 2 (Th2) cytokines.

methodsWe conducted a randomized trial in 204 CXCA survivors to test if psychosocial telephone counseling (PTC) could improve QOL compared to usual care (UC). Although PTC did not target SS, data were collected at baseline, 4 and 9 months post-enrollment using the Medical Outcomes Survey Social Support scale. Biospecimens were collected to investigate associations with patient-reported outcomes. Data were analyzed using multivariate linear models and stepwise regression.

resultsParticipants' mean age was 43. PTC participants experienced increasing SS compared to UC at 4 months (PTC-UC = 5.1; p = 0.055) and 9 months (PTC-UC = 6.0; p = 0.046). Higher baseline SS and increasing SS were independently associated with improved QOL at 4 and 9 months after adjusting for patient characteristics (p < 0.05). Differences between study arms were not statistically significant. Improvements in QOL at 4 months were observed with increases in emotional/informational and tangible SS. Increasing SS predicted significant longitudinal decreases in IL-4 and IL-13 at 4 months that were larger in the PTC arm (interactions p = 0.041 and p = 0.057, respectively).

conclusionImproved SS was significantly associated with improved QOL independent of patient characteristics and study arm. Decreasing Th2 cytokines with increasing SS and QOL are consistent with a biobehavioral paradigm in which modulation of the chronic stress response is associated with shifts in immune stance.

Indexed as

Cancer SurvivorsCytokinesQuality of LifeSocial SupportSurvivorshipUterine Cervical NeoplasmsAdultCounselingFemaleHumansInterleukin-13Interleukin-4Middle AgedTelephoneTh2 CellsCytokinesIL4 protein, humanInterleukin-13Interleukin-4Cancer survivorshipQuality of lifeSocial support

Identifiers

PMID30612237
PMCPMC6612537
OpenAlexW2908136132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.