Evidence map›Paper›PMID 30612202›Full record

Trial reportActa diabetologica2019

Exercise-induced improvements in glucose effectiveness are blunted by a high glycemic diet in adults with prediabetes.

Adithya Hari, Ciaràn Fealy, Thomas P J Solomon, Jacob M Haus, Karen R Kelly, Hope Barkoukis, John P Kirwan

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta diabetologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 3 countries.

Adithya HariDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Ciaràn FealyMaastricht University, Maastricht, The Netherlands.
Thomas P J SolomonUniversity of Birmingham, Birmingham, UK.
Jacob M HausUniversity of Michigan, Ann Arbor, MI, USA.
Karen R KellyWarfighter Performance Department, Naval Health Research Center, 140 Sylvester Road, San Diego, CA, USA.
Hope BarkoukisCase Western Reserve University, Cleveland, OH, USA.
John P KirwanDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. John.Kirwan@pbrc.edu.ORCID http://orcid.org/0000-0001-7321-9917
Case Western Reserve University · USCleveland Clinic Lerner College of Medicine · USMaastricht University · NLNaval Health Research Center · USPennington Biomedical Research Center · USUniversity of Birmingham · GBUniversity of Michigan · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Age, Exercise, Diet: Effects on Insulin ResistanceR01AG012834 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI KIRWAN, JOHN P. · 2004 to 2008
$1.9M
National Center for Research Resources 1UL1RR024989National Institute on Aging RO1 AG12834NCATS NIH HHS UL1 TR002548NCRR NIH HHS UL1 RR024989NIA NIH HHS R01 AG012834NIDDK NIH HHS P30 DK020572NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

aimsGlucose effectiveness (GE) refers to the ability of glucose to influence its own metabolism through insulin-independent mechanisms. Diminished GE is a predictor of progression to type 2 diabetes. Exercise training improves GE, however, little is known about how dietary interventions, such as manipulating the glycemic index of diets, interact with exercise-induced improvements in GE in at-risk populations.

methodsWe enrolled 33 adults with obesity and pre-diabetes (17 males, 65.7 ± 4.3 years, 34.9 ± 4.2 kg m

resultsBoth EX-LOG and EX-HIG groups had similar improvements in weight (8.6 ± 5.1 kg, P < 0.001), VO

conclusionsOur data suggest that a high glycemic index diet may suppress exercise-induced enhancement of GE, and this may be mediated through plasma FFAs.

Indexed as

ObesityPrediabetic StateAgedDiabetes Mellitus, Type 2Diet TherapyExercise TherapyFemaleGlucoseGlucose Tolerance TestGlycemic IndexHumansInsulin ResistanceMaleMiddle AgedTreatment OutcomeGlucoseAerobic exercise trainingDietGlucose effectivenessGlycemic indexHyperinsulinemic-euglycemic clampPrediabetes

Identifiers

PMID30612202
PMCPMC6530476
OpenAlexW2907048820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.