ReviewEuropean journal of applied physiology2019
The skeletal muscle fiber: a mechanically sensitive cell.
Review in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Effects of Resistance Training on Muscle Hypertrophy in Children and Adolescents: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Severe Muscle Deconditioning Triggers Early Extracellular Matrix Remodeling and Resident Stem Cell Differentiation into Adipocytes in Healthy Men.International journal of molecular sciences · 2022Trial
- PIEZO1 Mediates Myoblast Proliferation Under Simulated Microgravity.Annals of the New York Academy of Sciences · 2026Article
- Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance.Endocrine reviews · 2025Review
- Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes.FEBS open bio · 2025Article
- Impact of rAAV-shRNA treatment targeting mechanosensitive Ilk1 and Fermt2 in a mouse model of sepsis-induced muscle weakness.PloS one · 2025Article
- Aerobic mechanochemical reversible-deactivation radical polymerization.Nature communications · 2024Article
- A neuromorphic device mimicking synaptic plasticity under different body fluid KFundamental research · 2024Article
- Advancing cancer cachexia diagnosis with -omics technology and exercise as molecular medicine.Sports medicine and health science · 2024Review
- Aberrant evoked calcium signaling and nAChR cluster morphology in aFrontiers in cell and developmental biology · 2024Article
- The Plateau in Muscle Growth with Resistance Training: An Exploration of Possible Mechanisms.Sports medicine (Auckland, N.Z.) · 2024Review
- Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.Physiological reviews · 2023Review
- The emerging role of Piezo1 channels in skeletal muscle physiology.Biophysical reviews · 2023Review
- Intravenous Injection of Sodium Hyaluronate Diminishes Basal Inflammatory Gene Expression in Equine Skeletal Muscle.Animals : an open access journal from MDPI · 2023Article
- Beneficial Effects ofSports (Basel, Switzerland) · 2023Article
- Reversible Effects of Functional Mandibular Lateral Shift on Masticatory Muscles in Growing Rats.Biomedicines · 2023Article
- Induced Pluripotent Stem Cells for Tissue-Engineered Skeletal Muscles.International journal of molecular sciences · 2023Review
- Insight into muscle stem cell regeneration and mechanobiology.Stem cell research & therapy · 2023Review
- Mechanotransduction for Muscle Protein Synthesis via Mechanically Activated Ion Channels.Life (Basel, Switzerland) · 2023Review
- A century of exercise physiology: key concepts in muscle cell volume regulation.European journal of applied physiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plasticity of skeletal muscle, whether an increase in size, change in metabolism, or alteration in structural properties, is in a continuous state of flux largely dependent upon physical activity. Much of the past research has expounded upon these ever-changing aspects of the muscle fiber following exercise. Specifically, endocrine and paracrine signaling have been heavily investigated lending to much of the past literature comprised of such endocrinological dynamics following muscle activity. Mechanotransduction, the ability of a cell to convert a mechanical stimulus into an intracellular biochemical response, has garnered much less attention. Recent work, however, has demonstrated the physical continuity of the muscle fiber, specifically demonstrating a continuous physical link between the extracellular matrix (ECM), cytoskeleton, and nuclear matrix as a means to rapidly regulate gene expression following a mechanical stimulus. Similarly, research has shown mechanical stimuli to directly influence cytoplasmic signaling whether through oxidative adaptations, increased muscle size, or enhanced muscle integrity. Regrettably, minimal research has investigated the role that exercise may play within the mechanotransducing signaling cascades. This proposed line of study may prove paramount as muscle-related diseases greatly impact one's ability to lead an independent lifestyle along with contributing a substantial burden upon the economy. Thus, this review explores both biophysical and biochemical mechanotransduction, and how these signaling pathways may be influenced following exercise.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.