Evidence map›Paper›PMID 30612139›Full record

ArticleDiabetologia2019

Loss of X-box binding protein 1 in Müller cells augments retinal inflammation in a mouse model of diabetes.

Jing Yang, Chen Chen, Todd McLaughlin, Yaqin Wang, Yun-Zheng Le, Joshua J Wang, Sarah X Zhang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 48 citations in OpenAlex.

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  6. Diabetic retinopathy and Alzheimer's disease: Convergence of the unfolded protein response in neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jing YangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Chen ChenDepartment of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Todd McLaughlinDepartment of Ophthalmology, Ira G. Ross Eye Institute, University at Buffalo, State University of New York, 955 Main Street, Buffalo, NY, 14214, USA.
Yaqin WangDepartment of Ophthalmology, Ira G. Ross Eye Institute, University at Buffalo, State University of New York, 955 Main Street, Buffalo, NY, 14214, USA.
Yun-Zheng LeDepartment of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Joshua J WangDepartment of Ophthalmology, Ira G. Ross Eye Institute, University at Buffalo, State University of New York, 955 Main Street, Buffalo, NY, 14214, USA.
Sarah X ZhangDepartment of Ophthalmology, Ira G. Ross Eye Institute, University at Buffalo, State University of New York, 955 Main Street, Buffalo, NY, 14214, USA. xzhang38@buffalo.edu.
University at Buffalo, State University of New York · USUniversity of Oklahoma Health Sciences Center · USSun Yat-sen University · CN

Funding

ER Stress and Diabetic RetinopathyR01EY019949 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, SARAH X · 2010 to 2023
$5.5M
Study of the ER-mitochondria interface as a new target in diabetic retinopathyR21EY025061 · NEI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ZHANG, SARAH X · 2015 to 2016
$438k
NEI NIH HHS EY025061NEI NIH HHS R01 EY019949NEI NIH HHS R21 EY025061
6 · The paper itself

Abstract

aims/hypothesisMüller glia (MG) are major sources of retinal cytokines, and their activation is closely linked to retinal inflammation and vascular leakage in diabetic retinopathy. Previously, we demonstrated that X-box binding protein 1 (XBP1), a transcription factor activated by endoplasmic reticulum (ER) stress in diabetic retinopathy, is involved in regulation of inflammation in retinal endothelial cells. Now, we have explored the role of XBP1 and ER stress in the regulation of MG-derived proinflammatory factors, and their influence on vascular permeability in diabetic retinopathy.

methodsMG-specific conditional Xbp1 knockout (Xbp1

resultsXbp1 CONCLUSIONS/

interpretationOur results have revealed an important role of XBP1 and ER stress in MG-driven retinal inflammation, and suggest that targeting ER stress may represent a promising approach for the prevention and treatment of diabetic retinopathy.

Indexed as

AnimalsCapillary PermeabilityDiabetes Mellitus, ExperimentalDiabetic RetinopathyEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEpendymoglial CellsInflammationMiceRetinaX-Box Binding Protein 1Endoplasmic Reticulum Chaperone BiPHspa5 protein, mouseX-Box Binding Protein 1Diabetic retinopathyER stressInflammationMüller cellX-box binding protein 1

Identifiers

PMID30612139
PMCPMC6374194
OpenAlexW2907728742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.