Evidence map›Paper›PMID 30611909›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2019

Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis.

Danyang Li, Louisa E Jeffery, Carl Jenkinson, Stephanie R Harrison, Rene F Chun, John S Adams, Karim Raza, Martin Hewison

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

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  11. Vitamin D and the Immune System in Menopause: A Review.Journal of menopausal medicine · 2021
    Review
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  13. Article
  14. Review
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  18. Vitamin D, Autoimmune Disease and Rheumatoid Arthritis.Calcified tissue international · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Danyang LiInstitute of Metabolism and Systems Research, The University of Birmingham, Birmingham, B15 2TT, UK.
Louisa E JefferyInstitute of Translational Medicine, The University of Birmingham, Birmingham, B15 2TT, UK.
Carl JenkinsonInstitute of Metabolism and Systems Research, The University of Birmingham, Birmingham, B15 2TT, UK.
Stephanie R HarrisonInstitute of Metabolism and Systems Research, The University of Birmingham, Birmingham, B15 2TT, UK; Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, B18 7QH, UK.
Rene F ChunDepartment of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, CA 90095, USA.
John S AdamsDepartment of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Karim RazaDepartment of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, B18 7QH, UK; Institute of Inflammation and Ageing, Arthritis Research UK Rheumatoid Arthritis Pathogenesis Centre of Excellence and MRC Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, B15 2TT, UK.
Martin HewisonInstitute of Metabolism and Systems Research, The University of Birmingham, Birmingham, B15 2TT, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, B15 2TT, UK. Electronic address: m.hewison@bham.ac.uk.
University of Birmingham · GBSandwell & West Birmingham Hospitals NHS Trust · GBUniversity of California, Los Angeles · US

Funding

DBP and the bioavailability and function of vitamin DR01AR063910 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S, HEWISON, MARTIN · 2013 to 2017
$1.8M
Medical Research Council MR/P021220/1NIAMS NIH HHS R01 AR063910
6 · The paper itself

Abstract

Vitamin D-deficiency has been linked to inflammatory diseases including rheumatoid arthritis (RA). Studies to date have focused on the impact of serum 25-hydroxyvitamin D3 (25(OH)D3), an inactive form of vitamin D, on RA disease activity and progression. However, anti-inflammatory actions of vitamin D are likely to be mediated at sites of RA disease, namely the inflamed joint, and may involve other vitamin D metabolites notably the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)

Indexed as

24,25-Dihydroxyvitamin D 3AdultAgedAged, 80 and overArthritis, RheumatoidAvitaminosisCalcifediolCalcitriolFemaleHumansMaleMiddle AgedProhibitinsSynovial FluidYoung Adult24,25-Dihydroxyvitamin D 3CalcifediolCalcitriolPHB2 protein, humanProhibitinsFree vitamin DInflammatory diseaseRheumatoid arthritisSerumSynovial fluidVitamin DVitamin D binding protein

Identifiers

PMID30611909
PMCPMC6444051
OpenAlexW2907288588

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.