ArticleNeurobiology of learning and memory2019
Memory deficits in males and females long after subchronic immune challenge.
Article in Neurobiology of learning and memory, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Repeated, sustained inflammation affects hippocampal dependent learning and neuroinflammation across age and sex.Behavioural brain research · 2025Article
- Sex differences in sepsis outcomes across the lifespan: a population-based cohort study in Germany.Critical care (London, England) · 2025Article
- Neuroinflammatory history results in overlapping transcriptional signatures with heroin exposure in the nucleus accumbens and alters responsiveness to heroin in male rats.Translational psychiatry · 2024Article
- Early Post-Natal Immune Activation Leads to Object Memory Deficits in FemaleBiomedicines · 2024Article
- Genes Involved by Dexamethasone in Prevention of Long-Term Memory Impairment Caused by Lipopolysaccharide-Induced Neuroinflammation.Biomedicines · 2023Article
- Sex-dependent deficits in associative learning across multiple LPS doses.Physiology & behavior · 2023Article
- New perspectives on sex differences in learning and memory.Trends in endocrinology and metabolism: TEM · 2023Review
- Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection.Clinical science (London, England : 1979) · 2023Review
- Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment.Nature communications · 2023Article
- Chronic stress beginning in adolescence decreases spatial memory following an acute inflammatory challenge in adulthood.Behavioural brain research · 2023Article
- Effects of sex and pro-inflammatory cytokines on context discrimination memory.Behavioural brain research · 2023Article
- Current Understanding of Long-Term Cognitive Impairment After Sepsis.Frontiers in immunology · 2022Review
- Sex differences and similarities in the neuroimmune response to central administration of poly I:C.Journal of neuroinflammation · 2021Article
- Enduring and Sex-specific Changes in Hippocampal Gene Expression after a Subchronic Immune Challenge.Neuroscience · 2020Article
- Accelerated Deficits of Spatial Learning and Memory Resulting From Prenatal Inflammatory Insult Are Correlated With Abnormal Phosphorylation and Methylation of Histone 3 in CD-1 Mice.Frontiers in aging neuroscience · 2019Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Memory impairments and cognitive decline persist long after recovery from major illness or injury, and correlate with increased risk of later dementia. Here we developed a subchronic peripheral immune challenge model to examine delayed and persistent memory impairments in females and in males. We show that intermittent injections of either lipopolysaccharides or Poly I:C cause memory decline in both sexes that are evident eight weeks after the immune challenge. Importantly, we observed sex-specific patterns of deficits. Females showed impairments in object recognition one week after challenge that persisted for at least eight weeks. In contrast, males had intact memory one week after the immune challenge but exhibited broad impairments in memory tasks including object recognition, and both context and tone fear conditioning several months later. The differential patterns of memory deficits in males and in females were observed without sustained microglial activation or changes in blood-brain barrier permeability. Together, these data suggest that transient neuroimmune activity results in differential vulnerabilities of females and males to memory decline after immune challenge. This model will be an important tool for determining the mechanisms in both sexes that contribute to memory impairments that develop over the weeks and months after recovery from illness. Future studies using this model will provide new insights into the role of chronic inflammation in the pathogenesis of long-lasting memory decline and dementias.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.