Evidence map›Paper›PMID 30611870›Full record

ArticleExperimental hematology2019

Compounds targeting class II histone deacetylases do not cause panHDACI-associated impairment of megakaryocyte differentiation.

Damir Simic, Nianli Sang

Open access · bronzeAbstract read
In one paragraph

Article in Experimental hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Damir SimicDepartment of Biology, Drexel University, Philadelphia, PA; Janssen R&D, Preclinical Development & Safety, Johnson & Johnson, Spring House, PA, USA.
Nianli SangDepartment of Biology, Drexel University, Philadelphia, PA; Sidney Kimmel Cancer Center, Philadelphia, PA. Electronic address: nianli.sang@drexel.edu.
Johnson & Johnson (United States) · USSidney Kimmel Cancer Center · US

Funding

Repressing HIF-1: targets and mechanismsR01CA129494 · NCI · DREXEL UNIVERSITY · PI SANG, NIANLI · 2008 to 2012
$1.6M
NCI NIH HHS R01 CA129494
6 · The paper itself

Abstract

Histone deacetylase inhibitors (HDACIs) have demonstrated effectiveness against lymphomas and myelomas in clinical practice. However, common to all currently approved broad-acting HDACIs (panHDACIs) is dose-limiting thrombocytopenia, which has prevented wider use in cancer therapy. Using CD34

Indexed as

AnilidesAntigens, CD34Cell DifferentiationCell Line, TumorGATA1 Transcription FactorHematopoietic Stem CellsHistone Deacetylase InhibitorsHumansHydroxamic AcidsMegakaryocytesProteasome Endopeptidase ComplexProteolysisThrombocytopeniaAnilidesAntigens, CD34GATA1 protein, humanGATA1 Transcription FactorHistone Deacetylase InhibitorsHydroxamic AcidsProteasome Endopeptidase Complextubacin

Identifiers

PMID30611870
PMCPMC6456912
OpenAlexW2908398297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.