ArticleParasites & vectors2019
Silencing expression of the Rhipicephalus microplus vitellogenin receptor gene blocks Babesia bovis transmission and interferes with oocyte maturation.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- RmTIL, a cysteine-rich protein as a putative microbiota modulator from Rhipicephalus microplus tick.Parasitology research · 2026Article
- Mutualism in disguise: A mosquito parasite with mixed transmission mode displays mutualistic traits promoting oogenesis.PLoS pathogens · 2026Article
- Comparative immunoinformatic analysis of Rhipicephalus microplus cocktail vaccine targets.Parasites & vectors · 2025Article
- In silico prediction of the binding structure between vitellogenin and vitellogenin receptor of Haemaphysalis longicornis.The Journal of veterinary medical science · 2025Article
- Article
- Fourteen anti-tick vaccine targets are variably conserved in cattle fever ticks.Parasites & vectors · 2025Article
- Starvation Metabolism Adaptations in Tick Embryonic Cells BME26.International journal of molecular sciences · 2024Article
- Periviscerokinin (CapParasites & vectors · 2022Article
- The Impact of RNA Interference in Tick Research.Pathogens (Basel, Switzerland) · 2022Article
- Developmental transcriptomics throughout the embryonic developmental process of Rhipicephalus turanicus reveals stage-specific gene expression profiles.Parasites & vectors · 2022Article
- Preliminary Investigation intoMedical sciences (Basel, Switzerland) · 2022Article
- Vitellogenin-2 Accumulation in the Fat Body and Hemolymph ofFrontiers in cellular and infection microbiology · 2022Article
- The vitellogenin receptor functionality of the migratory locust depends on its phosphorylation by juvenile hormone.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Tick Ecdysteroid Hormone, Global Microbiota/Microorganisms · 2021Article
- Challenges in Tick-Borne Pathogen Detection: The Case forPathogens (Basel, Switzerland) · 2021Review
- Catalogue of stage-specific transcripts in Ixodes ricinus and their potential functions during the tick life-cycle.Parasites & vectors · 2020Article
- Time-resolved proteomic profile of Amblyomma americanum tick saliva during feeding.PLoS neglected tropical diseases · 2020Article
- Identification of proteins expressed by Babesia bigemina kinetes.Parasites & vectors · 2019Article
- Transcriptome and Proteome Response ofFrontiers in physiology · 2019Article
- Vitellogenin Receptor as a Target for Tick Control: A Mini-Review.Frontiers in physiology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRhipicephalus microplus is an efficient biological vector of Babesia bovis, a causative agent of bovine babesiosis. Babesia bovis is passed transovarially to the next generation of ticks, which then transmit the parasite to naïve animals. Due to the importance of the R. microplus ovary for tick reproduction and transmission of B. bovis, we investigated the hypothesis that silencing vitellogenin receptor gene expression in the ovary during tick feeding on B. bovis-infected cattle would affect parasite transmission to the next generation of ticks.
resultsSilencing expression of the vitellogenin receptor in the ovary by RNA interference, resulted in reduced tick fertility. We observed reduced egg production (i.e. reduced weight of eggs), a lower rate of embryonic development, and a reduction in hatching. Analysis of individual larvae by PCR confirmed that RNAi mediated downregulation of the R. microplus vitellogenin receptor and also interfered with transovarial transmission of B. bovis. None of the larvae (0/58) from the RmVgR dsRNA-injected group were PCR-positive, whereas 12% (7/58) and 17% (10/58) of larvae from the non-injected and buffer-injected control groups, respectively, were infected with B. bovis.
conclusionsThe combined effects of reduced fecundity and reduced infection in surviving larvae resulting from silencing indicate that vitellogenin receptor is essential for tick reproduction and may play a vital role in B. bovis transmission.
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Registered trials
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