Evidence map›Paper›PMID 30611303›Full record

ArticleSkeletal muscle2019

Defects in sarcolemma repair and skeletal muscle function after injury in a mouse model of Niemann-Pick type A/B disease.

V Michailowsky, H Li, B Mittra, S R Iyer, D A G Mazála, M Corrotte, Y Wang, E R Chin, R M Lovering, N W Andrews

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal muscle, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Mechanism of static loading injury in human skeletal muscle cells.American journal of translational research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

V MichailowskyDepartment of Cell Biology and Molecular Genetics, University of Maryland, 2134 Bioscience Research Building, College Park, MD, 20742-5815, USA.
H LiDepartment of Kinesiology, University of Maryland School of Public Health, College Park, MD, USA.
B MittraDepartment of Cell Biology and Molecular Genetics, University of Maryland, 2134 Bioscience Research Building, College Park, MD, 20742-5815, USA.
S R IyerDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA.
D A G MazálaCenter for Genetic Medicine Research, Children's National Health System, Washington DC, USA.
M CorrotteDepartment of Cell Biology and Molecular Genetics, University of Maryland, 2134 Bioscience Research Building, College Park, MD, 20742-5815, USA.
Y WangProteomics Core Facility, College of Computer, Mathematical and Natural Sciences, University of Maryland, College Park, MD, USA.
E R ChinDepartment of Kinesiology, University of Maryland School of Public Health, College Park, MD, USA.
R M LoveringDepartment of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA.
N W AndrewsDepartment of Cell Biology and Molecular Genetics, University of Maryland, 2134 Bioscience Research Building, College Park, MD, 20742-5815, USA. andrewsn@umd.edu.ORCID 0000-0002-0611-2412
Bioscience Research · USUniversity of Maryland, Baltimore · USUniversity of Maryland, College Park · USChildren's National · USCytokinetics (United States) · US

Funding

Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7M
Genetics and Genomics of Muscle Postdoctoral Training ProgramT32AR056993 · NIAMS · CHILDREN'S RESEARCH INSTITUTE · PI JAISWAL, JYOTI K, PARTRIDGE, TERENCE A · 2010 to 2019
$2.2M
Orbitrap Fusion Tribrid Mass SpectrometerS10OD019938 · OD · UNIV OF MARYLAND, COLLEGE PARK · PI FENSELAU, CATHERINE C · 2015 to 2015
$600k
Skeletal muscle repair after injury and Niemann-Pick type A/B DiseaseR21AR071011 · NIAMS · UNIV OF MARYLAND, COLLEGE PARK · PI ANDREWS, NORMA WINDSOR · 2017 to 2018
$381k
NIAMS NIH HHS R21 AR071011NIAMS NIH HHS T32 AR007592NIAMS NIH HHS T32 AR056993NIH HHS S10 OD019938
6 · The paper itself

Abstract

backgroundNiemann-Pick disease type A (NPDA), a disease caused by mutations in acid sphingomyelinase (ASM), involves severe neurodegeneration and early death. Intracellular lipid accumulation and plasma membrane alterations are implicated in the pathology. ASM is also linked to the mechanism of plasma membrane repair, so we investigated the impact of ASM deficiency in skeletal muscle, a tissue that undergoes frequent cycles of injury and repair in vivo.

methodsUtilizing the NPDA/B mouse model ASM

resultsASM

conclusionsSkeletal muscle fibers from ASM

Indexed as

Excitation Contraction CouplingAnimalsCalcium SignalingDisease Models, AnimalFemaleMaleMice, KnockoutMuscle Fibers, SkeletalMuscle, SkeletalNiemann-Pick Disease, Type ANiemann-Pick Disease, Type BProteomeRecovery of FunctionSarcolemmaSphingomyelin PhosphodiesteraseProteomeSphingomyelin PhosphodiesteraseAcid sphingomyelinaseCalciumLysosomePlasma membrane repairSkeletal muscle

Identifiers

PMID30611303
PMCPMC6320626
OpenAlexW2907914341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.