SynthesisImplementation science : IS2019
Systematic review of the Exploration, Preparation, Implementation, Sustainment (EPIS) framework.
Synthesis in Implementation science : IS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 696 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adaptation of the World Health Organization Surgical Safety Checklist to High-Income Healthcare Settings - Phase III: Site Testing Study
Multisite Implementation of COMPRENDO (ChildhOod Malignancy Peer REsearch NavigatiOn) to Improve Participation of Hispanic Children in Cancer Clinical Trials
Testing an mHealth Digital Dashboard to Improve Quality of Delivery of Evidence-based Interventions That Promote Family Mental Health and Functioning in Rwanda: A Hybrid Type 3 Study
Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery
Who cites it
696 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Real-World Performance Measurement of Patient-Centered Clinical Decision Support Tools: Qualitative Study.JMIR formative research · 2026Pooled it
- Implementation science frameworks and strategies to promote adoption of and adherence to oncology clinical practice guidelines in low- and middle-income countries: a scoping review.BMC global and public health · 2026Pooled it
- Systematic Review of Organizational Strategies to Promote the Sustainability and Scale-Up of Mental Health Interventions to Advance Youth Psychological Wellbeing.Prevention science : the official journal of the Society for Prevention Research · 2026Pooled it
- Exploring long-term follow-up of effective implementation trials in schools: a secondary review.Frontiers in public health · 2026Pooled it
- Improving Explainability and Integrability of Medical AI to Promote Health Care Professional Acceptance and Use: Mixed Systematic Review.Journal of medical Internet research · 2025Pooled it
- Characterizing Behaviors That Influence the Implementation of Digital-Based Interventions in Health Care: Systematic Review.Journal of medical Internet research · 2025Pooled it
- Applying system support mapping combined with the matrixed multiple case study approach to identify and analyse implementation determinants: lessons from a multi-site implementation study in German neonatal intensive care units.BMC health services research · 2026Trial
- Determinants of Successful Implementation: A Mixed-Methods Evaluation of a Team-Based Telehealth Hypertension Management Program for Underserved Patients.Journal of the American Heart Association · 2026Trial
- Targeted social and behavior change communication (SBCC) in a high adolescent pregnancy setting of Bangladesh: a cluster-randomized study protocol engaging key family members.Implementation science : IS · 2026Trial
- Delivering a family-based child mental health promotion program among two resettled refugee communities during the COVID-19 pandemic: Lessons learned in a hybrid type II implementation-effectiveness randomized controlled trial.American journal of community psychology · 2026Trial
- Sustainable improvement of interprofessional care for better resident outcomes: protocol for the INTERSCALE hybrid type III effectiveness cluster-randomized trial comparing individualized and collaborative delivery of an evidence-based care model for long-term care.Implementation science : IS · 2026Trial
- Feasibility and effectiveness of a health educational intervention to improve navigation of health insurance benefits for in vitro fertilization: a randomized controlled trial.Journal of assisted reproduction and genetics · 2026Trial
- Effects of a leadership-focused implementation strategy on uptake of digital measurement-based care in mental health clinics: a cluster randomized trial.Translational behavioral medicine · 2026Trial
- Economic Evaluation of Tobacco Treatments From the Screen ASSIST Lung Cancer Screening Trial.JAMA network open · 2026Trial
- Understanding mechanisms of multi-level implementation strategies for autism interventions in a randomized trial across service systems.Implementation science : IS · 2025Trial
- Effectiveness of Multilevel Implementation Strategies for Autism Interventions: Outcomes of Two Linked Implementation Trials.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Trial
- Exploring Fit in a Mobile Health Intervention for Alcohol Use Disorder: Qualitative Study.JMIR mHealth and uHealth · 2025Trial
- "I Just Need Guidance Through This Maze I'm Going Through": Addressing Unmet Basic and Mental Health Needs to Facilitate Engagement in HIV Prevention Services in the Context of Stimulant Use.AIDS patient care and STDs · 2026Article
- Organizational Factors Impacting Implementation of Evidence-based Practices for Autistic Youth: A Mixed Methods Evaluation of Virginia's Community Mental Health System.Administration and policy in mental health · 2026Article
- Learning Health System Implementation: Building a Hub-and-Spoke Model for Hypertension Management Through the QI Hub.Journal of general internal medicine · 2026Article
636 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundEffective implementation of evidence-based practices (EBPs) remains a significant challenge. Numerous existing models and frameworks identify key factors and processes to facilitate implementation. However, there is a need to better understand how individual models and frameworks are applied in research projects, how they can support the implementation process, and how they might advance implementation science. This systematic review examines and describes the research application of a widely used implementation framework, the Exploration, Preparation, Implementation, Sustainment (EPIS) framework.
methodsA systematic literature review was performed to identify and evaluate the use of the EPIS framework in implementation efforts. Citation searches in PubMed, Scopus, PsycINFO, ERIC, Web of Science, Social Sciences Index, and Google Scholar databases were undertaken. Data extraction included the objective, language, country, setting, sector, EBP, study design, methodology, level(s) of data collection, unit(s) of analysis, use of EPIS (i.e., purpose), implementation factors and processes, EPIS stages, implementation strategy, implementation outcomes, and overall depth of EPIS use (rated on a 1-5 scale).
resultsIn total, 762 full-text articles were screened by four reviewers, resulting in inclusion of 67 articles, representing 49 unique research projects. All included projects were conducted in public sector settings. The majority of projects (73%) investigated the implementation of a specific EBP. The majority of projects (90%) examined inner context factors, 57% examined outer context factors, 37% examined innovation factors, and 31% bridging factors (i.e., factors that cross or link the outer system and inner organizational context). On average, projects measured EPIS factors across two of the EPIS phases (M = 2.02), with the most frequent phase being Implementation (73%). On average, the overall depth of EPIS inclusion was moderate (2.8 out of 5).
conclusionThis systematic review enumerated multiple settings and ways the EPIS framework has been applied in implementation research projects, and summarized promising characteristics and strengths of the framework, illustrated with examples. Recommendations for future use include more precise operationalization of factors, increased depth and breadth of application, development of aligned measures, and broadening of user networks. Additional resources supporting the operationalization of EPIS are available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.