ArticleLipids in health and disease2019
The gender- and age- dependent relationships between serum lipids and cognitive impairment: a cross-sectional study in a rural area of Xi'an, China.
Article in Lipids in health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Vascular risk factor variability and cognitive impairment in older adults a community-based retrospective study.Scientific reports · 2025Article
- Concussion-Related Cognitive and Lipid Changes in Retired UK Rugby Players Study.International journal of molecular sciences · 2025Article
- Associations between serum lipid levels and cognitive impairment in hypertensive patients: a case-control study.BMC neurology · 2025Article
- A machine learning-based model for predicting the risk of cognitive frailty in elderly patients on maintenance hemodialysis.Scientific reports · 2025Article
- Association between low cognitive performance and diabetes-related health indicators across racial and ethnic groups in adults with diabetes.Diabetes, obesity & metabolism · 2024Article
- Decreased neuronal excitability in hypertriglyceridemia hamsters with acute seizures.Frontiers in neurology · 2024Article
- Association Between the Ratios of Selenium to Several Elements and Mild Cognitive Impairment in the Elderly.Biological trace element research · 2023Article
- Associations between circulating cardiovascular disease risk factors and cognitive performance in cognitively healthy older adults from the NuAge study.Frontiers in aging neuroscience · 2023Article
- Correlation between serum lipid profiles and cognitive impairment in old age: a cross-sectional study.General psychiatry · 2023Article
- Difference in the Standard and Novel Lipid Profile Parameters Between Patients With Alzheimer's Disease and Vascular Dementia Stratified by the Degree of Cognitive Impairment.Materia socio-medica · 2022Article
- Differential proteomic analysis of mouse cerebrums with high-fat diet (HFD)-induced hyperlipidemia.PeerJ · 2022Article
- Effects of a Smoke-Free Policy in Xi'an, China: Impact on Hospital Admissions for Acute Ischemic Heart Disease and Stroke.Frontiers in public health · 2022Article
- Association between Serum Lipid Parameters and Cognitive Performance in Older Adults.Journal of clinical medicine · 2021Article
- Sex difference in flux of 27-hydroxycholesterol into the brain.British journal of pharmacology · 2021Article
- The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence.Nutrients · 2021Review
- The Relationships Between Lipid Accumulation Product Levels and Cognitive Decline Over 4 Years in a Rural Area of Xi'an, China.Frontiers in aging neuroscience · 2021Article
- Sex Differences in the Association Between Obesity and Cognitive Impairment in a Low-Income Elderly Population in Rural China: A Population-Based Cross-Sectional Study.Frontiers in neurology · 2021Article
- Elevated HDL Levels Linked to Poorer Cognitive Ability in Females With Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study.Lipids in health and disease · 2020Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSerum lipids [total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG)] are risk factors for stroke, but the relationships between serum lipids and cognitive impairment have not been verified completely. In this study, we studied the relationships between serum lipids and cognitive impairment and explored whether gender and age had effects on the relationships.
methodsIn this cross-sectional study, we collected serum lipids and cognitive function information from 1762 participants (aged 40-85). Univariate analysis, multivariate analysis, and both gender- and age-based stratified multivariate analysis were used.
resultsIn the entire sample set, there was no significant correlation between serum lipid parameters (TC, LDL-C, HDL-C and TG) and cognitive impairment. In both gender- and age-based stratified multivariate analysis, high serum TC was positively associated with cognitive impairment in the elderly (> 55) male participants (OR = 4.404, 95% CI = 1.264-15.344, p = 0.02), and high serum LDL-C was positively correlated with cognitive impairment in the elderly female subjects (OR = 2.496, 95% CI = 1.057-5.896, p = 0.037), while high serum TG was negatively associated with cognitive impairment in the middle-aged (≤ 55) male participants (OR = 0.157, 95% CI = 0.051-0.484, p = 0.001).
conclusionsThe relationships between serum lipids and cognitive impairment are gender- and age- dependent, with high serum TC and LDL-C may be risk factors of cognitive impairment in the elderly male and female subjects respectively, while high serum TG may be protector of cognitive impairment in the middle-aged male participants.
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