Evidence map›Paper›PMID 30611275›Full record

ArticleNutrition journal2019

The Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910) addendum: neuroimaging and gut microbiota protocol.

Tamara Simpson, Saurenne Deleuil, Nicole Echeverria, Mrudhula Komanduri, Helen Macpherson, Chao Suo, Shakuntla Gondalia, Masoumeh Tangestani Fard, Andrew Pipingas, Andrew Scholey and 1 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Natural Molecules for Brain Health and Resilience.International journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tamara SimpsonCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia.
Saurenne DeleuilCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia.
Nicole EcheverriaCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia.
Mrudhula KomanduriCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia.
Helen MacphersonCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia.
Chao SuoBrain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Australia.
Shakuntla GondaliaCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia.
Masoumeh Tangestani FardCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia.
Andrew PipingasCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia.
Andrew ScholeyCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia.
Con StoughCentre for Human Psychopharmacology, Swinburne University of Technology, PO Box 218, Hawthorn, Victoria, Melbourne, Australia. cstough@swin.edu.au.

Funding

Australian Research Council Discovery DP1093825
6 · The paper itself

Abstract

backgroundThe Australian Research Council Longevity Intervention (ARCLI) was designed to investigate the effects of two active supplements, Pycnogenol and Bacopa monnieri (CDRI08) on cognitive performance in a cohort of elderly participants. An additional antioxidant supplement has been included into the trial. A neuroimaging component has also been added to the ARCLI study to investigate the neurochemical biomarkers of oxidative stress in vivo, as well as structural and functional changes associated with ageing and oxidative stress. Faecal biomarkers of gut microflora will also be analysed to investigate if gut microbiota are associated with domains of cognition (e.g., attention, processing speed, memory), mood or other ARCLI outcome variables. The aim of this paper is to update the published methods of the ARCLI clinical trial before it is completed, and data analysis commences.

methodsARCLI is a randomised, placebo controlled, double-blind, now 4-arm clinical trial including neuroimaging and gut microflora sub-studies. Along with the demographic, haematological, mood, cardiovascular and cognitive assessments described in the initial protocol, 80 eligible participants from the overall study pool of ~ 400 will be recruited into the neuroimaging study and undergo scans at baseline, 3 months and 12 months. Proton magnetic resonance spectroscopy, resting state functional connectivity and arterial spin labelled perfusion sequences are neuroimaging techniques included for each MRI visit in the study. Similarly, approximately 300 participants from the main study pool will be recruited to provide faecal samples at baseline, 3 months and 12 months so that the gut microbiome can be studied. DISCUSSION: ARCLI is 12-month intervention study, currently underway with a group of older adults, investigating a range of outcomes and their association with ageing. The additional measurements in the ARCLI trial will further the understanding of the underlying mechanisms associated with healthy ageing and may provide insights into novel preventative therapeutic strategies for maintaining cognitive and brain health into old age.

trial registrationAustralia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12611000487970 .

Indexed as

AgingCognitionGastrointestinal MicrobiomeLongevityNeuroimagingAffectAntioxidantsAustraliaBrainCardiovascular SystemDietary SupplementsDouble-Blind MethodHealth PromotionHumansMagnetic Resonance ImagingOxidative StressAntioxidantsPlacebosAgeingAntioxidantBacopaCognitionGlutathioneMagnetic resonance imagingMagnetic resonance spectroscopyNeuroimagingPycnogenol

Identifiers

PMID30611275
PMCPMC6321680

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.