ArticleBMC musculoskeletal disorders2019
Knee osteoarthritis patients with more subchondral cysts have altered tibial subchondral bone mineral density.
Article in BMC musculoskeletal disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Altered subchondral bone mineral density in painful knee osteoarthritis without cysts: a comparative analysis of lateral and medial regions.BMC musculoskeletal disorders · 2025Article
- Cystic lesions in osteoarthritis and osteonecrosis of the femoral head : a comparative analysis of 3D distribution, microstructure, and histology.Bone & joint research · 2025Article
- Relationship between DXA measured systemic bone mineral density and subchondral bone cysts in postmenopausal female patients with knee osteoarthritis: a cross-sectional study : Osteoarthritis cysts and bone mineral density.BMC musculoskeletal disorders · 2024Article
- Biomechanical analysis of different techniques for residual bone defect from tibial plateau bone cyst in total knee arthroplasty.Frontiers in bioengineering and biotechnology · 2024Article
- CT in osteoarthritis: its clinical role and recent advances.Skeletal radiology · 2023Review
- Quantification of cartilage and subchondral bone cysts on knee specimens based on a spectral photon-counting computed tomography.Scientific reports · 2023Article
- Bone marrow lesions: plugging the holes in our knowledge using animal models.Nature reviews. Rheumatology · 2023Review
- A Massive Proximal Tibia Geode - Can we Afford to Miss it?Journal of orthopaedic case reports · 2023Article
- Subchondral Bone Cyst Development in Osteoarthritis: From Pathophysiology to Bone Microarchitecture Changes and Clinical Implementations.Journal of clinical medicine · 2023Review
- Comparison of clinical-CT segmentation techniques for measuring subchondral bone cyst volume in glenohumeral osteoarthritis.Journal of experimental orthopaedics · 2023Article
- Novel technique of detecting inflammatory and osseous changes in the glenohumeral joint associated with patient age and weight using FDG- and NaF-PET imaging.American journal of nuclear medicine and molecular imaging · 2023Article
- The role of bone mineral density and cartilage volume to predict knee cartilage degeneration.European journal of translational myology · 2022Article
- Virtual monoenergetic images from photon-counting spectral computed tomography to assess knee osteoarthritis.European radiology experimental · 2022Article
- Magnetic Resonance Imaging-Assessed Subchondral Cysts and Incident Knee Pain and Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study.Arthritis & rheumatology (Hoboken, N.J.) · 2022Observational
- Bleeding with iron deposition and vascular remodelling in subchondral cysts: A newly discovered feature unique to haemophilic arthropathy.Haemophilia : the official journal of the World Federation of Hemophilia · 2021Article
- Time-dependently Appeared Microenvironmental Changes and Mechanism after Cartilage or Joint Damage and the Influences on Cartilage Regeneration.Organogenesis · 2021Review
- Osteoporosis is associated with varus deformity in postmenopausal women with knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2021Article
- Association between knee alignment, osteoarthritis disease severity, and subchondral trabecular bone microarchitecture in patients with knee osteoarthritis: a cross-sectional study.Arthritis research & therapy · 2020Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundSubchondral bone cysts are a widely observed, but poorly understood, feature in patients with knee osteoarthritis (OA). Clinical quantitative computed tomography (QCT) has the potential to characterize cysts in vivo but it is unclear which specific cyst parameters (e.g., number, size) are associated with clinical signs of OA, such as disease severity or pain. The objective of this study was to use QCT-based image-processing techniques to characterize subchondral tibial cysts in patients with knee OA and to explore relationships between proximal tibial subchondral cyst parameters and subchondral bone density as well as clinical characteristics of OA (alignment, joint space narrowing (JSN), OA severity, pain) in patients with knee OA.
methodsThe preoperative knee of 42 knee arthroplasty patients was scanned using QCT. Patient characteristics were obtained, including OA severity, knee pain, JSN, and alignment. We used 3D image processing techniques to obtain cyst parameters including: cyst number, cyst number per proximal tibial volume, cyst volume per proximal tibial volume, as well as maximum and average cyst volume across the proximal tibia, as well as regional bone mineral density (BMD) excluding cysts. We used Spearman's correlation coefficients to explore associations between patient characteristics and cyst parameters.
resultsAt both the medial and lateral compartments of the proximal tibia, greater cyst number and volume were associated with higher BMD. At the lateral region, cyst number and volume were also associated with lateral OA severity, lateral JSN, alignment and sex. Pain was not associated with any cyst parameters at any region.
conclusionCyst number and volume were associated with BMD at both the medial and lateral compartments. Lateral cyst number and volume were also associated with joint alignment, OA severity, JSN and sex. This is the first study to use clinical QCT to explore subchondral tibial cysts in patients with knee OA and provides further evidence of the relationships between subchondral cysts and clinical OA characteristics.
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