Evidence map›Paper›PMID 30611212›Full record

ArticleBMC cardiovascular disorders2019

Circulating microRNA-1 in the diagnosis and predicting prognosis of patients with chest pain: a prospective cohort study.

Tong Su, Xiaonan Shao, Xiaopu Zhang, Zhijun Han, Chengjian Yang, Xun Li

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Article in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tong SuDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.
Xiaonan ShaoDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China.
Xiaopu ZhangDepartment of Neurology, The Third People's Hospital of Changzhou, Changzhou, 213001, Jiangsu, China.
Zhijun HanDepartment of Cardiology, The Second People's Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi, 214000, Jiangsu, China.
Chengjian YangDepartment of Cardiology, The Second People's Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi, 214000, Jiangsu, China. 326061944@qq.com.
Xun LiDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China. doctor0756@163.com.ORCID 0000-0003-2184-1864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the early diagnostic and prognostic value of microRNA-1 in patients with acute chest pain.

methodsThis study enrolled 341 patients attacked by chest pain within 3 h, and another 100 volunteers as control group. Circulating microRNA-1 was collected and determined by real-time quantitative reverse transcription-polymerase chain reaction. The clinical follow-up period was 720 days.

resultsThere were 174 patients in acute myocardial infarction (AMI) group, 167 in non-AMI group. The relative expression of microRNA-1 was significantly increased within 3 h in AMI group, and it continued rising within 12 h, lower at 24 h than that 12 h in AMI group without reperfusion therapy. Otherwise, microRNA-1 concentration was markedly low at 12 h after primary percutaneous coronary intervention in AMI group. The 95% reference range of circulating microRNA-1 was 0.171-0.653. It was significantly available for microRNA-1 to early diagnose AMI with an optimal cutoff value of 2.215 and diagnostic accuracy could be improved when combined with cardiac troponin I. It was not statistically significant for microRNA-1 to forecast future AMI but might prognose mortality of 720 days in chest pain patients. In patients with chest pain, microRNA-1 concentration was high with major adverse cardiac events within 30 days, low with high overall survival within 720 days.

conclusionsCirculating microRNA-1 might diagnose early AMI and predict the prognosis of patients with chest pain.

Indexed as

AgedAngina PectorisCase-Control StudiesCirculating MicroRNAEarly DiagnosisFemaleGenetic MarkersHumansMaleMicroRNAsMiddle AgedMyocardial InfarctionPredictive Value of TestsPrognosisProspective StudiesRisk FactorsCirculating MicroRNAGenetic MarkersMicroRNAsMIRN1 microRNA, humanTroponin IAcute myocardial infarctionBiomarkerCardiac troponinChest painMicroRNA-1

Identifiers

PMID30611212
PMCPMC6321730

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.