ArticleBiomaterials2019
Individual response variations in scaffold-guided bone regeneration are determined by independent strain- and injury-induced mechanisms.
Article in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 82 citations in OpenAlex.
- Design and performance analysis of bionic trabecular bone scaffold structure based on Voronoi.Journal of biological engineering · 2025Article
- Computational optimization of 3D printed bone scaffolds using orthogonal array-driven FEA and neural network modeling.Scientific reports · 2025Article
- Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo.Scientific reports · 2024Article
- Osteoinductive micro-nano guided bone regeneration membrane for in situ bone defect repair.Stem cell research & therapy · 2024Article
- Article
- The role of collagen and crystallinity in the physicochemical properties of naturally derived bone grafts.Regenerative biomaterials · 2024Article
- Poly-ε-Caprolactone 3D-Printed Porous Scaffold in a Femoral Condyle Defect Model Induces Early Osteo-Regeneration.Polymers · 2023Article
- Design and performance analysis of 3D-printed stiffness gradient femoral scaffold.Journal of orthopaedic surgery and research · 2023Article
- Scaffold Guided Bone Regeneration for the Treatment of Large Segmental Defects in Long Bones.Biomedicines · 2023Review
- Computational design and evaluation of the mechanical and electrical behavior of a piezoelectric scaffold: a preclinical study.Frontiers in bioengineering and biotechnology · 2023Article
- The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesis.Frontiers in bioengineering and biotechnology · 2023Article
- Bioreactor analyses of tissue ingrowth, ongrowth and remodelling around implants: An alternative to live animal testing.Frontiers in bioengineering and biotechnology · 2023Article
- Review
- A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation.Journal of nanobiotechnology · 2022Article
- A mechanobiological computer optimization framework to design scaffolds to enhance bone regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: AnFrontiers in bioengineering and biotechnology · 2022Article
- A multiscale optimisation method for bone growth scaffolds based on triply periodic minimal surfaces.Biomechanics and modeling in mechanobiology · 2021Article
- Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration - an in silico analysis.Biomechanics and modeling in mechanobiology · 2021Article
- Current interpretations on theBiomaterials and biosystems · 2021Article
- Bioscaffolds embedded with regulatory modules for cell growth and tissue formation: A review.Bioactive materials · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
This study explored the regenerative osteogenic response in the distal femur of sheep using scaffolds having stiffness values within, and above and below, the range of trabecular bone apparent modulus. Scaffolds 3D-printed from stiff titanium and compliant polyamide were implanted into a cylindrical metaphyseal defect 15 × 15 mm. After six weeks, bone ingrowth varied between 7 and 21% of the scaffold pore volume and this was generally inversely proportional to scaffold stiffness. The individual reparative response considerably varied among the animals, which could be divided into weak and strong responders. Notably, bone regeneration specifically within the interior of the scaffold was inversely proportional to scaffold stiffness and was strain-driven in strongly-responding animals. Conversely, bone regeneration at the periphery of the defect was injury-driven and equal in all scaffolds and in all strongly- and weakly-responding animals. The observation of the strain-driven response in some, but not all, animals highlights that scaffold compliance is desirable for triggering host bone regeneration, but scaffold permanence is important for the load-bearing, structural role of the bone-replacing device. Indeed, scaffolds may benefit from being nonresorbable and mechanically reliable for those unforeseeable cases of weakly responding recipients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.