Evidence map›Paper›PMID 30610918›Full record

ArticleActa biomaterialia2019

Aligned hydrogel tubes guide regeneration following spinal cord injury.

Courtney M Dumont, Mitchell A Carlson, Mary K Munsell, Andrew J Ciciriello, Katerina Strnadova, Jonghyuck Park, Brian J Cummings, Aileen J Anderson, Lonnie D Shea

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Courtney M DumontDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.
Mitchell A CarlsonDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.
Mary K MunsellDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.
Andrew J CicirielloDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.
Katerina StrnadovaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA; Department of Nonwovens and Nanofibrous Materials, Technical University of Liberec, Studentska 1402/2, Liberec 461 17, Czech Republic.
Jonghyuck ParkDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA.
Brian J CummingsInstitute for Memory Impairments and Neurological Disorders (iMIND), University of California, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA; Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA; Department of Physical Medicine and Rehabilitation, University of California, Irvine, CA, USA.
Aileen J AndersonInstitute for Memory Impairments and Neurological Disorders (iMIND), University of California, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA; Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA; Department of Physical Medicine and Rehabilitation, University of California, Irvine, CA, USA.
Lonnie D SheaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48105, USA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: ldshea@umich.edu.

Funding

Controlled Release Scaffolds for Nerve RegenerationR01EB005678 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDERSON, AILEEN J, SHEA, LONNIE D · 2007 to 2018
$6.0M
Measuring Signaling Pathway Dynamics During Tissue Growth in HydrogelsR01CA214384 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JERUSS, JACQUELINE SARA, SHEA, LONNIE D · 2017 to 2021
$1.8M
NCI NIH HHS R01 CA214384NIBIB NIH HHS R01 EB005678
6 · The paper itself

Abstract

Directing the organization of cells into a tissue with defined architectures is one use of biomaterials for regenerative medicine. To this end, hydrogels are widely investigated as they have mechanical properties similar to native soft tissues and can be formed in situ to conform to a defect. Herein, we describe the development of porous hydrogel tubes fabricated through a two-step polymerization process with an intermediate microsphere phase that provides macroscale porosity (66.5%) for cell infiltration. These tubes were investigated in a spinal cord injury model, with the tubes assembled to conform to the injury and to provide an orientation that guides axons through the injury. Implanted tubes had good apposition and were integrated with the host tissue due to cell infiltration, with a transient increase in immune cell infiltration at 1 week that resolved by 2 weeks post injury compared to a gelfoam control. The glial scar was significantly reduced relative to control, which enabled robust axon growth along the inner and outer surface of the tubes. Axon density within the hydrogel tubes (1744 axons/mm

Indexed as

AnimalsAxonsCicatrixCross-Linking ReagentsFemaleHindlimbHydrogelsLocomotionMaleimidesMice, Inbred C57BLMicrospheresMyelin SheathNerve RegenerationNeurogliaPolyethylene GlycolsPolymerizationCross-Linking ReagentsHydrogelsmaleimideMaleimidesPolyethylene GlycolsAxon elongationModular biomaterialSpinal cord injuryTissue repair

Identifiers

PMID30610918
PMCPMC6369008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.