ArticleCroatian medical journal2018
In vitro effects of hydrogen peroxide on rat uterine contraction before and during pregnancy.
Article in Croatian medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Status of Oxidative Stress during Low-Risk Labour: Preliminary Data.International journal of environmental research and public health · 2022Article
- Effects of supplementing sow diets during late gestation with Pennisetum purpureum on antioxidant indices, immune parameters and faecal microbiota.Veterinary medicine and science · 2021Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the in vitro effect of hydrogen peroxide (H2O2) on uterine contractions in pregnant and non-pregnant rats.
methodsThe study was performed at the Department of Physiology, College of Medicine, King Saud University from December 2016 to October 2017. Intact uterine samples were obtained from non-pregnant (n=7-8) and term-pregnant (n=6-7) rats. Small longitudinal uterine strips were dissected and mounted in an organ bath. Isometric force measurements were used to assess the effect of 400, 800, and 1000 μM H2O2 on spontaneous uterine contractions and contractions induced by oxytocin (5 nM), high calcium (Ca+2) solution (6 mmol/L), and high potassium chloride (KCl) solution (60 mmol/L).
resultsIn both term-pregnant and non-pregnant uterine strips, H2O2 elicited a biphasic response, consisting of a transient contraction followed by a persistent decrease in spontaneously generated contractions, contractions induced by oxytocin, and contractions induced by high Ca+2 (all P<0.01, compared with controls) in a concentration-dependent manner. The effect of H2O2 was more pronounced in non-pregnant than in pregnant rats (P<0.05). In both groups, H2O2 failed to relax uterine strips pre-contracted with high-KCl solution (P>0.05 compared with controls).
conclusionH2O2 was shown to be a potent uterine relaxant in pregnant and non-pregnant states. The pregnant uterus better withstood the inhibitory effect of H2O2 than non-pregnant uterus.
Indexed as
Identifiers
30610775PMC6330773W2914739918What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.