Evidence map›Paper›PMID 30610740›Full record

SynthesisJournal of neurovirology2019

High-dose corticosteroids for acute cytomegalovirus-associated transverse myelitis in the immunocompetent patient: a case report and systematic review.

A Budhram, Y Liu, M Krawczyk, T L H Chan, J G Burneo, S M Hosseini-Moghaddam, C Shoesmith

Abstract readCase ReportsSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of neurovirology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Isolated Cytomegalovirus Optic Neuritis in an Immunocompetent Patient.European journal of case reports in internal medicine · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

A BudhramDepartment of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada. adrian.budhram@lhsc.on.ca.
Y LiuDepartment of Medicine, Division of General Internal Medicine, Western University, London, Ontario, N6A 5A5, Canada.
M KrawczykDepartment of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada.
T L H ChanDepartment of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada.
J G BurneoDepartment of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada.
S M Hosseini-MoghaddamDepartment of Medicine, Division of Infectious Diseases, Western University, London, Ontario, N6A 5A5, Canada.
C ShoesmithDepartment of Clinical Neurological Sciences, Division of Neurology, University Hospital, Western University, 339 Windermere Rd, London, ON, N6A 5A5, Canada.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present an immunocompetent patient with transverse myelitis (TM) during acute cytomegalovirus (CMV) infection, as evidenced by a reactive serum CMV IgM and CMV viremia. The patient had an excellent outcome after receiving only high-dose methylprednisolone. Given concerns that practitioners may have around the use of immunosuppressive therapy for this potentially infectious myelopathy, we systematically reviewed the literature to assess outcomes after administration of high-dose corticosteroids to this population. Despite severe disease at clinical nadir with inability to ambulate, immunocompetent patients with acute CMV-associated TM who received high-dose corticosteroids had good clinical outcomes 1 month to 1 year after presentation.

Indexed as

Adrenal Cortex HormonesAnti-Inflammatory AgentsCytomegalovirus InfectionsHumansImmunocompetenceMaleMethylprednisoloneMiddle AgedMyelitis, TransverseAdrenal Cortex HormonesAnti-Inflammatory AgentsMethylprednisoloneCorticosteroidsCytomegalovirusImmunocompetentMethylprednisoloneMyelitis

Identifiers

PMID30610740
OpenAlexW2906786350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.