ArticleInternal and emergency medicine2019
Prevalence and outcome of diuretic resistance in heart failure.
Article in Internal and emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01647932 (Safety and Efficacy of the Combination of Loop Diuretics With Thiazide-type Diuretics in Patients With Decompensated Heart Failure), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of the Combination of Loop Diuretics With Thiazide-type Diuretics in Patients With Decompensated Heart Failure: a Double-blind, Randomized, Placebo-controlled Trial (CLOROTIC Trial).
Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Effectiveness of Zhuling decoction on diuretic resistance in patients with heart failure: a randomized, controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Trial
- Factors Predicting Diuretic Resistance in Patients With Acute Decompensated Heart Failure.Journal of clinical medicine research · 2026Article
- Diuretic resistance during emergency treatment of acute heart failure: incidence and correlation with 30-day readmission.American journal of translational research · 2026Article
- Diuretic Response Prediction With MELD Score in Heart Failure.Clinical cardiology · 2025Article
- Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure.ESC heart failure · 2025Article
- Prognostic effect of the combined use of thiazides and loop diuretics at discharge following a hospitalization for acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Urea, TMAO, betaine and other osmolytes as endogenous diuretics in heart failure and hypertension.Heart failure reviews · 2025Review
- Serum chloride and the response to combining loop and thiazide diuretics for acute heart failure: the ALCALOTIC study.Internal and emergency medicine · 2025Observational
- Sodium-glucose co-transporter 2 inhibitors: Prospects for canine myxomatous mitral valve disease and finding the "right drug" and the "right dose" for dogs.The Journal of veterinary medical science · 2025Review
- Diuretic activity of hydro-alcoholic extract and solvent fractions of Solanum lycopersicum L. leaves in mice.Scientific reports · 2025Article
- Diuretic resistance in cardiorenal syndrome: mechanisms, monitoring and phenotype-tailored management.Frontiers in cardiovascular medicine · 2025Review
- Pharmacological Therapy of HFrEF in 2025: Navigating New Advances and Old Unmet Needs in An Eternal Balance Between Progress and Perplexities.Cardiac failure review · 2025Review
- Combinational Diuretics in Heart Failure.Current heart failure reports · 2024Review
- Diuretic Treatment in Heart Failure: A Practical Guide for Clinicians.Journal of clinical medicine · 2024Review
- Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions-Part II: Combination Therapy.Current heart failure reports · 2024Review
- Multidisciplinary approach to patients with heart failure and kidney disease: preliminary experience of an integrated cardiorenal unit.Clinical kidney journal · 2023Article
- Peritoneal ultrafiltration in older adult patients with advanced heart failure.Internal and emergency medicine · 2023Article
- Efficacy and safety of early ultrafiltration in patients with acute decompensated heart failure: a meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Diuretic resistance and the role of albumin in congestive heart failure.Drugs in context · 2023Review
- Dose of furosemide before admission predicts diuretic efficiency and long-term prognosis in acute heart failure.ESC heart failure · 2022Observational
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Authors and funding
10 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diuretic resistance (DR) is common in patients with decompensated heart failure (HF), and is associated with adverse outcomes. To determine the prevalence of DR and its impact on survival among patients with decompensated HF, we prospectively evaluated the prevalence and influence on prognosis of DR (defined as persistent congestion despite ≥ 80 mg of furosemide per day) in a cohort of elderly patients from the Spanish HF registry (RICA) admitted for an acute decompensation of HF. Patients with new-onset HF were excluded. From the global cohort of 2067 patients, 435 (21%; 95% CI 19.3%-22.7%) patients met criteria for DR. Patients with DR had more comorbidities (hypercholesterolemia, diabetes mellitus, valvular disease, chronic kidney disease, and cancer) and a worse functional status compared to patients without DR. In addition, patients with DR had a higher proportion of ischemic etiology, more advanced functional class and lower left ventricular ejection fraction values. After 1 year of follow-up, all-cause mortality was higher in patients with DR with an adjusted hazard ratio of 1.37 (95% CI 1.06-1.79; p = 0.018). The prevalence of DR in a cohort of elderly patients admitted for acute HF decompensation is 21%. DR is an independent predictor of 1-year mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.