Evidence map›Paper›PMID 30610252›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2019

Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer's disease.

Antoine Leuzy, Claudia Cicognola, Konstantinos Chiotis, Laure Saint-Aubert, Laetitia Lemoine, Niels Andreasen, Henrik Zetterberg, Keqiang Ye, Kaj Blennow, Kina Höglund and 1 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

  1. Nuclear medicine and molecular imaging · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Novel avenues of tau research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  6. Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Antoine LeuzyDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Claudia CicognolaDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Konstantinos ChiotisDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Laure Saint-AubertDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Laetitia LemoineDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Niels AndreasenTheme Aging, Karolinska University Hospital, Stockholm, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Keqiang YePathology & Laboratory Medicine, Experimental Pathology, Emory University School of Medicine, Atlanta, GA, USA.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Kina HöglundDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Agneta NordbergDepartment of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden. agneta.k.nordberg@ki.se.
Karolinska Institutet · SEUniversity of Gothenburg · SEEmory University · USKarolinska University Hospital · SESahlgrenska University Hospital · SEUK Dementia Research Institute · GB

Funding

Swedish Research Council 05817, 06086
6 · The paper itself

Abstract

purposeStudies comparing CSF and PET tau biomarkers have included only commercial CSF assays examining specific phosphorylation sites (e.g. threonine 181, P-tau

methodsFourteen Alzheimer's disease (AD) patients (seven prodromal, seven dementia) underwent [

resultsWhile the levels of all forms of CSF tau were found to be inversely associated with baseline [

conclusionOur findings suggest that neurodegeneration may modulate the relationship between CSF and PET tau biomarkers, and that, by comparison to P-tau

Indexed as

Positron-Emission TomographyAgedAlzheimer DiseaseFemaleFluorodeoxyglucose F18HumansLongitudinal StudiesMaleMiddle Agedtau ProteinsFluorodeoxyglucose F18tau Proteins[18F]FDG[18F]THK5317Alzheimer’s diseaseCSFPET imagingTau

Identifiers

PMID30610252
PMCPMC6451715
OpenAlexW2908411107

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.