ArticleMolecular psychiatry2020
Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality.
Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Genetic basis of cannabis use: a systematic review.BMC medical genomics · 2021Pooled it
- Using Mendelian randomization analysis to better understand the relationship between mental health and substance use: a systematic review.Psychological medicine · 2021Pooled it
- Neurodevelopmental Effects of Cannabis Use in Adolescents and Emerging Adults with ADHD: A Systematic Review.Harvard review of psychiatryPooled it
- Cannabis Use in Adults Who Screen Positive for Attention Deficit/Hyperactivity Disorder: CANreduce 2.0 Randomized Controlled Trial Subgroup Analysis.Journal of medical Internet research · 2022Trial
- ADHD Symptoms and Cannabis Use: The Role of Cannabinoid Receptor 1 and Neural Response Inhibition.medRxiv : the preprint server for health sciences · 2026Article
- Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies.Molecular psychiatry · 2026Review
- Multivariate genome-wide association analysis of dyslexia and quantitative reading skill improves gene discovery.Translational psychiatry · 2025Article
- Association Between Cannabis Use and Neuropsychiatric Disorders: A Two-sample Mendelian Randomization Study.Alpha psychiatry · 2025Article
- Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations.Psychological medicine · 2025Article
- Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study.Molecular psychiatry · 2025Article
- The Separation of Adult ADHD Inattention and Hyperactivity-Impulsivity Symptoms and Their Association with Problematic Short-Video Use: A Structural Equation Modeling Analysis.Psychology research and behavior management · 2025Article
- ADHD and Cannabis Use in College Students: Examining Indirect Effects of Coping Motives.Substance use & misuse · 2025Article
- Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders.Psychiatry research · 2024Article
- The impact of recreational cannabis legalization on youth: the Colorado experience.European child & adolescent psychiatry · 2024Review
- Cannabis use and its association with psychopathological symptoms in a Swiss adult population: a cross-sectional analysis.Frontiers in public health · 2024Article
- UK Medical Cannabis Registry: An analysis of clinical outcomes of medicinal cannabis therapy for attention-deficit/hyperactivity disorder.Neuropsychopharmacology reports · 2023Article
- Towards a New Dynamic Interaction Model of Adolescent CUD Manifestation, Prevention, and Treatment: A Narrative Review.Psychoactives · 2023Article
- Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes.Neuroscience and biobehavioral reviews · 2023Review
- Review
- Mendelian randomization analysis for attention deficit/hyperactivity disorder: studying a broad range of exposures and outcomes.International journal of epidemiology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 6 institutions in 4 countries.
Funding
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a severely impairing neurodevelopmental disorder with a prevalence of 5% in children and adolescents and of 2.5% in adults. Comorbid conditions in ADHD play a key role in symptom progression, disorder course and outcome. ADHD is associated with a significantly increased risk for substance use, abuse and dependence. ADHD and cannabis use are partly determined by genetic factors; the heritability of ADHD is estimated at 70-80% and of cannabis use initiation at 40-48%. In this study, we used summary statistics from the largest available meta-analyses of genome-wide association studies (GWAS) of ADHD (n = 53,293) and lifetime cannabis use (n = 32,330) to gain insights into the genetic overlap and causal relationship of these two traits. We estimated their genetic correlation to be r
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.