ArticleNature communications2019
A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Identification of a TCR signature in peripheral blood derived CD4+ T cells, associated with chronic chikungunya disease, suggests a conducive, female-biased, background immune profile.Frontiers in immunology · 2026Article
- Integrative analysis of serum lipids and chronic gastritis: causal insights from mendelian randomization and experimental models.Lipids in health and disease · 2025Article
- The impact of lipidome on intervertebral disk degeneration, low back pain, and sciatica: a Mendelian randomization study.Scientific reports · 2025Article
- Mendelian randomization study of lipid species reveals causal relationship with syphilis.AMB Express · 2025Article
- Sensing mycobacteria through unconventional pathways.The Journal of clinical investigation · 2025Article
- A structural perspective of how T cell receptors recognize the CD1 family of lipid antigen-presenting molecules.The Journal of biological chemistry · 2024Review
- Liposomes have a direct effect on multiple myeloma: a Mendelian randomization study.Frontiers in oncology · 2024Article
- Immunogenic molecules associated with gut bacterial cell walls: chemical structures, immune-modulating functions, and mechanisms.Protein & cell · 2023Review
- Article
- CD1 displays its own negative regulators.Current opinion in immunology · 2023Review
- Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.Nature immunology · 2023Article
- CD1B is a Potential Prognostic Biomarker Associated with Tumor Mutation Burden and Promotes Antitumor Immunity in Lung Adenocarcinoma.International journal of general medicine · 2022Article
- Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases.International journal of molecular sciences · 2021Review
- CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules.Science immunology · 2021Article
- Novel Molecular Insights into Human Lipid-Mediated T Cell Immunity.International journal of molecular sciences · 2021Review
- Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle.Scientific reports · 2021Article
- Human skin is colonized by T cells that recognize CD1a independently of lipid.The Journal of clinical investigation · 2021Article
- Role of Group 1 CD1-Restricted T Cells in Host Defense and Inflammatory Diseases.Critical reviews in immunology · 2021Article
- Human γδ T cells recognize CD1b by two distinct mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein.Biomolecules · 2020Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 6 countries.
Funding
Abstract
CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human membrane phospholipids presented by CD1b. These T-cells discriminate between two major types of lipids, sphingolipids and phospholipids, but were broadly cross-reactive towards diverse phospholipids including phosphatidylcholine, phosphatidylinositol and phosphatidylethanolamine. The crystal structure of a representative TCR bound to CD1b-phosphatidylcholine provides a molecular mechanism for this promiscuous recognition. We observe a lateral escape channel in the TCR, which shunted phospholipid head groups sideways along the CD1b-TCR interface, without contacting the TCR. Instead the TCR recognition site involved the neck region phosphate that is common to all major self-phospholipids but absent in sphingolipids. Whereas prior studies have focused on foreign lipids or rare self-lipids, we define a new molecular mechanism of promiscuous recognition of common self-phospholipids including those that are known targets in human autoimmune disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.