Evidence map›Paper›PMID 30610188›Full record

ArticleNature communications2019

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.

R C Nayak, S Hegde, M J Althoff, A M Wellendorf, F Mohmoud, J Perentesis, M Reina-Campos, D Reynaud, Y Zheng, M T Diaz-Meco and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. SATB2 expression in hematolymphoid neoplasms.Journal of hematopathology · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

R C NayakDivision of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.
S HegdeDivision of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.ORCID http://orcid.org/0000-0001-8228-9570
M J AlthoffDivision of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.
A M WellendorfDivision of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.
F MohmoudGraduate Program of Cancer & Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
J PerentesisDivision of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.
M Reina-CamposCancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.
D ReynaudDivision of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.
Y ZhengDivision of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA.
M T Diaz-MecoCancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0003-0147-0998
J MoscatCancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.ORCID http://orcid.org/0000-0002-9442-3834
J A CancelasDivision of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229, USA. jose.cancelas@uc.edu.
Cincinnati Children's Hospital Medical Center · USSanford Burnham Prebys Medical Discovery Institute · USUniversity of Cincinnati Medical Center · US

Funding

Training Program in Cancer TherapeuticsT32CA117846 · NCI · UNIVERSITY OF CINCINNATI · PI PRICE, CAROLYN M, TAKIAR, VINITA · 2006 to 2022
$6.5M
Cincinnati Center for Excellence in Molecular HematologyP30DK090971 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ZHENG, YI · 2010 to 2015
$4.0M
Protein Kinase Cz targets in Intestinal Cancer Stem CellsR01CA172025 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MOSCAT, JORGE · 2013 to 2017
$2.2M
Mechanisms of cell death and autophagy in intestinal epithelial cells in inflammation and cancerR01CA207177 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOSCAT, JORGE · 2017 to 2021
$2.1M
G-CSF in Human Severe Congenital NeutropeniaR01GM110628 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI CANCELAS, JOSE A., LUTZKO, CAROLYN M · 2015 to 2018
$1.2M
Scribble in hematopoietic stem cell activityF31HL132468 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI ALTHOFF, MARK JORDAN · 2016 to 2019
$147k
NCI NIH HHS R01 CA172025NCI NIH HHS R01 CA207177NCI NIH HHS T32 CA117846NHLBI NIH HHS F31 HL132468NIDDK NIH HHS P30 DK090971NIGMS NIH HHS R01 GM110628
6 · The paper itself

Abstract

Epigenetically regulated transcriptional plasticity has been proposed as a mechanism of differentiation arrest and resistance to therapy. BCR-ABL leukemias result from leukemic stem cell/progenitor transformation and represent an opportunity to identify epigenetic progress contributing to lineage leukemogenesis. Primary human and murine BCR-ABL

Indexed as

AnimalsB-Lymphocytescdc42 GTP-Binding ProteinCell Transformation, NeoplasticChromatinDNA-Binding ProteinsEpigenesis, GeneticFusion Proteins, bcr-ablGene Expression Regulation, NeoplasticHumansLeukemiaMatrix Attachment Region Binding ProteinsMicePrecursor Cells, B-LymphoidProtein Kinase CSignal Transductioncdc42 GTP-Binding ProteinChromatinDNA-Binding ProteinsETV5 protein, humanFusion Proteins, bcr-ablMatrix Attachment Region Binding ProteinsPKC-3 proteinProtein Kinase CSATB2 protein, humanTranscription Factors

Identifiers

PMID30610188
PMCPMC6320370
OpenAlexW2907419173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.