ArticleNature communications2019
Experimental evidence of symmetry breaking of transition-path times.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Experimentally achieving minimal dissipation via thermodynamically optimal transport.Nature communications · 2025Article
- Kinetics and dynamics of oligonucleotide hybridization.Nature reviews. Chemistry · 2025Review
- General theory for localizing the where and when of entropy production meets single-molecule experiments.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- DNA Carrier-Assisted Molecular Ping-Pong in an Asymmetric Nanopore.Nano letters · 2023Article
- Waiting Time Distributions in Hybrid Models of Motor-Bead Assays: A Concept and Tool for Inference.International journal of molecular sciences · 2023Article
- First-passage statistics of colloids on fractals: Theory and experimental realization.Science advances · 2022Article
- Crowding breaks the forward/backward symmetry of transition times in biased random walks.The Journal of chemical physics · 2021Article
- Direct detection of molecular intermediates from first-passage times.Science advances · 2020Article
- Optimizing Brownian escape rates by potential shaping.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Slow Transition Path Times Reveal a Complex Folding Barrier in a Designed Protein.Frontiers in chemistry · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While thermal rates of state transitions in classical systems have been studied for almost a century, associated transition-path times have only recently received attention. Uphill and downhill transition paths between states at different free energies should be statistically indistinguishable. Here, we systematically investigate transition-path-time symmetry and report evidence of its breakdown on the molecular- and meso-scale out of equilibrium. In automated Brownian dynamics experiments, we establish first-passage-time symmetries of colloids driven by femtoNewton forces in holographically-created optical landscapes confined within microchannels. Conversely, we show that transitions which couple in a path-dependent manner to fluctuating forces exhibit asymmetry. We reproduce this asymmetry in folding transitions of DNA-hairpins driven out of equilibrium and suggest a topological mechanism of symmetry breakdown. Our results are relevant to measurements that capture a single coordinate in a multidimensional free energy landscape, as encountered in electrophysiology and single-molecule fluorescence experiments.
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