Evidence map›Paper›PMID 30610163›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis.

Joseph C Lownik, Jessica L Wimberly, Daniel H Conrad, Rebecca K Martin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Systematic analysis of potential targets of the curcumin analog pentagamavunon-1 (PGV-1) in overcoming resistance of glioblastoma cells to bevacizumab.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2021
    Article
  3. Article
  4. Autoimmunity in 2019.Clinical reviews in allergy & immunology · 2020
    Review
  5. Article
  6. Article
  7. Targeting ADAM10 in Cancer and Autoimmunity.Frontiers in immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joseph C LownikCenter for Clinical and Translational Research, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298.
Jessica L WimberlyVirginia Commonwealth University, Richmond, VA 23284.
Daniel H ConradDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298; and daniel.conrad@vcuhealth.org rebecca.martin@vcuhealth.org.ORCID 0000-0002-4791-2694
Rebecca K MartinDepartment of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298; and daniel.conrad@vcuhealth.org rebecca.martin@vcuhealth.org.
Virginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
STRUCTURE/FUNCTION OF THE LYMPHOCYTE FCE RECEPTORR01AI018697 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, REBECCA KELLEY · 1985 to 2018
$6.5M
NCI NIH HHS P30 CA016059NIAID NIH HHS R01 AI018697
6 · The paper itself

Abstract

The role of ICOS and its ligand (ICOSL) have both been shown to be essential for proper humoral responses as well as autoimmune Ab development in mouse models of lupus. In this paper, we report a specific role for the metalloprotease ADAM10 on B cells in regulating both ICOSL and ICOS in a mouse model of increased humoral immunity using B6

Indexed as

Immunity, HumoralADAM10 ProteinAmyloid Precursor Protein SecretasesAnimalsAutoantibodiesAutoimmunityB-LymphocytesCell ProliferationDisease Models, AnimalDisease ProgressionGene Expression RegulationInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinLupus Erythematosus, SystemicMembrane ProteinsMiceADAM10 ProteinAdam10 protein, mouseAmyloid Precursor Protein SecretasesAutoantibodiesIcosl protein, mouseIcos protein, mouseInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinMembrane ProteinsMicroRNAsMirn146 microRNA, mouse

Identifiers

PMID30610163
PMCPMC6344316
OpenAlexW2907362293

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.