ArticleJournal of immunology (Baltimore, Md. : 1950)2019
Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim.
Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Sonal JangalweProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.ORCID 0000-0002-2464-4711
Varun N KapoorDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
Jia XuIBM Watson Health, Cambridge, MA 02142.
Nomeda GirniusDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115; and.
Norman J KennedyProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.
Yvonne J K EdwardsProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.ORCID 0000-0001-8505-3168
Raymond M WelshDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA 01605.
Roger J DavisProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.ORCID 0000-0002-0130-1652
Michael A BrehmProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605; michael.brehm@umassmed.edu.ORCID 0000-0001-6813-3262
Funding
Novel humanized mouse model developed from cord blood CD34 positive HSC and autologous iPS cell derived thymusR01AI132963 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, MAEHR, RENE · 2017 to 2021
$4.4M
Deciphering the molecular basis of T1D in human cells using functional genomicsDP3DK111898 · NIDDK · HARVARD UNIVERSITY · PI CARR, STEVEN A, MAEHR, RENE · 2016 to 2016
$4.2M
Humanized Mouse Avatars for T1DUC4DK104218 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, DALEY, GEORGE Q · 2014 to 2014
$4.1M
Metabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6M
Development and Validation of Novel NSG Mouse Models for Human Stem Cell TherapyR24OD018259 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, GREINER, DALE LESLIE · 2014 to 2017
$3.0M
Combinatorial Beta Cell-Specific Cytokine Therapy to Reverse Type I DiabetesR01DK103546 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 2015 to 2018
$1.5M
IMMUNITY AND VIRUS DISEASER01AI017672 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WELSH, RAYMOND M · 1985 to 2003
Apoptosis of CD8 T cells is an essential mechanism that maintains immune system homeostasis, prevents autoimmunity, and reduces immunopathology. CD8 T cell death also occurs early during the response to both inflammation and costimulation blockade (CoB). In this article, we studied the effects of a combined deficiency of Fas (extrinsic pathway) and Bim (intrinsic pathway) on early T cell attrition in response to lymphocytic choriomeningitis virus infection and during CoB during transplantation. Loss of Fas and Bim function in
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim. · full record | OpenQuestion