Evidence map›Paper›PMID 30610112›Full record

ArticleEMBO molecular medicine2019

Cerebral malaria is associated with differential cytoadherence to brain endothelial cells.

Janet Storm, Jakob S Jespersen, Karl B Seydel, Tadge Szestak, Maurice Mbewe, Ngawina V Chisala, Patricia Phula, Christian W Wang, Terrie E Taylor, Christopher A Moxon and 2 more

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 2 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.

  1. Pooled it
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  12. mBio · 2026
    Article
  13. bioRxiv : the preprint server for biology · 2026
    Article
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  20. Evasive mechanisms of human VSG and PfEMP1 antigens with link to Vaccine scenario: a review.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Janet StormDepartment of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK janet.storm@lstmed.ac.uk Alister.Craig@lstmed.ac.uk.ORCID 0000-0001-7812-4220
Jakob S JespersenDepartment of International Health, Immunology & Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4930-5900
Karl B SeydelCollege of Medicine, University of Malawi, Blantyre, Malawi.
Tadge SzestakDepartment of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK.
Maurice MbeweMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Ngawina V ChisalaMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Patricia PhulaMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Christian W WangDepartment of International Health, Immunology & Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark.
Terrie E TaylorBlantyre Malaria Project, College of Medicine, University of Malawi, Blantyre, Malawi.
Christopher A MoxonInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Thomas LavstsenDepartment of International Health, Immunology & Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3044-4249
Alister G CraigDepartment of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK janet.storm@lstmed.ac.uk Alister.Craig@lstmed.ac.uk.ORCID 0000-0003-0914-6164
University of Liverpool · GBUniversity of Copenhagen · DKLiverpool School of Tropical Medicine · GBUniversity of Malawi · MW

Funding

Discovery of novel vascular therapies targeting PfEMP1-mediated cytoadhesion in severe malariaR01HL130678 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI LAVSTSEN, THOMAS, MOSNIER, LAURENT OLIVIER · 2015 to 2018
$2.0M
NHLBI NIH HHS R01 HL130678Wellcome Trust 095507
6 · The paper itself

Abstract

Sequestration of

Indexed as

Cell AdhesionBrainCells, CulturedChildChild, PreschoolEndothelial CellsErythrocytesFemaleHumansInfantMalaria, CerebralMaleModels, BiologicalPlasmodium falciparumcerebral malariacytoadherencepaediatric patient isolatesPfEMP1Plasmodium falciparum

Identifiers

PMID30610112
PMCPMC6365927
OpenAlexW2906801391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.