Evidence map›Paper›PMID 30610107›Full record

ArticleMolecular cancer research : MCR2019

Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.

Irina Lerman, Xiaoting Ma, Christina Seger, Aerken Maolake, Maria de la Luz Garcia-Hernandez, Javier Rangel-Moreno, Jessica Ackerman, Kent L Nastiuk, Martha Susiarjo, Stephen R Hammes

Abstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Neutrophils in cancer carcinogenesis and metastasis.Journal of hematology & oncology · 2021
    Review
  10. Article
  11. Article
  12. Regulated Cell Death in Urinary Malignancies.Frontiers in cell and developmental biology · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Targeting the Immune system and Epigenetic Landscape of Urological Tumors.International journal of molecular sciences · 2020
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Irina LermanDivision of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
Xiaoting MaDivision of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
Christina SegerDivision of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
Aerken MaolakeDepartment of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York.
Maria de la Luz Garcia-HernandezDivision of Allergy/Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
Javier Rangel-MorenoDivision of Allergy/Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
Jessica AckermanDepartment of Pathology, University of Rochester Medical Center, Rochester, New York.
Kent L NastiukDepartment of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York.
Martha SusiarjoDepartment of Environmental Medicine, University of Rochester Medical Center, Rochester, New York.
Stephen R HammesDivision of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York. stephen_hammes@urmc.rochester.edu.
University of Rochester Medical Center · USRoswell Park Comprehensive Cancer Center · US

Funding

Estrogen Signaling in a Mouse Model for LymphangioleiomyomatosisR01CA193583 · NCI · UNIVERSITY OF ROCHESTER · PI HAMMES, STEPHEN R. · 2016 to 2020
$1.7M
Paxillin as a Liaison between Extranuclear and Intranuclear Steroid SignalingR01GM101709 · NIGMS · UNIVERSITY OF ROCHESTER · PI HAMMES, STEPHEN R. · 2013 to 2016
$1.2M
Role of Neutrophil Elastase in Castration-Sensitive and Resistant Prostate CancerF30CA203517 · NCI · UNIVERSITY OF ROCHESTER · PI LERMAN, IRINA · 2016 to 2019
$197k
NCI NIH HHS F30 CA203517NCI NIH HHS R01 CA193583NIGMS NIH HHS R01 GM101709
6 · The paper itself

Abstract

Granulocytic myeloid infiltration and resultant enhanced neutrophil elastase (NE) activity is associated with poor outcomes in numerous malignancies. We recently showed that NE expression and activity from infiltrating myeloid cells was high in human prostate cancer xenografts and mouse

Indexed as

AnimalsCell Line, TumorDisease ProgressionEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticHistonesHumansInflammationMaleMiceMice, NudePromoter Regions, GeneticProstatic NeoplasmsRNA, MessengerSerpinsTransfectionEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humanHistonesRNA, MessengerSERPINB1 protein, humanSerpins

Identifiers

PMID30610107
PMCPMC6445715
OpenAlexW2908052958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.