Trial reportPediatrics2019
Patterns of Prenatal Alcohol Use That Predict Infant Growth and Development.
Trial report in Pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- Developmental Trajectory of Auditory Brainstem Deficits in a Mouse Model of Fetal Alcohol Spectrum Disorders.Developmental neurobiology · 2026Article
- What Do We Know About Alcohol Consumption During Pregnancy and Fetal Alcohol Spectrum Disorder in Nigeria? A Narrative Review.Health science reports · 2026Article
- FASD Science and Policy Depend on Deeply Phenotyped Prospective Birth Cohorts.Alcohol, clinical & experimental research · 2026Article
- Assessment of maternal health and behavior during pregnancy in the HEALthy Brain and Child Development Study: Rationale and approach.Developmental cognitive neuroscience · 2025Article
- Prenatal alcohol exposure and health at midlife: Self-reported health outcomes in two cohorts.Alcohol, clinical & experimental research · 2024Article
- The Impact of Prenatal Alcohol Exposure on Longitudinal Growth, Nutritional Status, and Insulin-Like Growth Factor 1 in Early Childhood in Leyte, the Philippines.The Journal of pediatrics · 2024Article
- The association between depression and alcohol use among pregnant adults in the USA.Archives of women's mental health · 2024Article
- Breastfeeding and neurodevelopment in infants with prenatal alcohol exposure.Pediatric research · 2024Article
- Prenatal Substance Exposure.Annual review of developmental psychology · 2023Article
- Prenatal alcohol exposure and cognition at midlife: Evidence of fluid cognition deficits in two cohorts.Alcohol, clinical & experimental research · 2023Article
- Low to Moderate Prenatal Alcohol Exposure and Neurodevelopmental Outcomes: A Narrative Review and Methodological Considerations.Alcohol research : current reviews · 2023Review
- Alcohol-related dysmorphic features as predictors of neurodevelopmental delay in infants and preschool-aged children: Results from a birth cohort in Ukraine.Alcoholism, clinical and experimental research · 2022Article
- Is Public Health Response to the Phenomenon of Alcohol Use during Pregnancy Adequate to the Polish Women's Needs?International journal of environmental research and public health · 2022Review
- Trajectories of prenatal alcohol exposure and behavioral outcomes: Findings from a community-based sample.Drug and alcohol dependence · 2022Article
- A data driven approach to identify trajectories of prenatal alcohol consumption in an Australian population-based cohort of pregnant women.Scientific reports · 2022Article
- Article
- Prenatal particulate matter exposure and mitochondrial mutational load at the maternal-fetal interface: Effect modification by genetic ancestry.Mitochondrion · 2022Article
- Objective assessment of alcohol consumption in early pregnancy using phosphatidylethanol: a cross-sectional study.BMC pregnancy and childbirth · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies have had inconsistent findings regarding the quantity and frequency of prenatal alcohol exposure (PAE) that lead to deficits in growth and neurodevelopment. This may be due to imprecise methods of exposure classification. Our objective in this study was to employ longitudinal trajectory modeling of maternal drinking patterns associated with infant growth or neurodevelopmental deficits to a homogenous sample of mothers and infants.
methodsFrom a sample of 471 pregnant women prospectively enrolled in a longitudinal study in the Ukraine, we performed a longitudinal cluster analysis of drinking patterns across gestation. We employed multivariable regression analyses to determine if each trajectory group was associated with infant weight, length, or head circumference at birth or psychomotor or mental deficits in infancy.
resultsWe identified 5 distinct PAE trajectory groups: minimal or no PAE throughout gestation, low-to-moderate PAE with discontinuation early in gestation, low-to-moderate PAE sustained across gestation, moderate-to-high PAE with reduction early in gestation, and high PAE sustained across gestation. The highest-trajectory group was associated with deficits in infant weight and length at birth and deficits in psychomotor and mental performance at 6 to 12 months of age. Although confidence intervals overlapped, low-to-moderate sustained use was more strongly associated with most negative infant outcomes than moderate-to-high PAE with early reduction.
conclusionsWith these findings, we confirm that high, sustained PAE confers the highest risk for adverse infant outcomes but demonstrate that even low-to-moderate PAE continued across gestation is associated with certain deficits. This approach may be used to help clinicians identify high-risk infants for targeted early intervention.
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