Evidence map›Paper›PMID 30610016›Full record

ArticleEMBO reports2019

APEX2-mediated RAB proximity labeling identifies a role for RAB21 in clathrin-independent cargo sorting.

Tomas Del Olmo, Annie Lauzier, Caroline Normandin, Raphaëlle Larcher, Mia Lecours, Dominique Jean, Louis Lessard, Florian Steinberg, François-Michel Boisvert, Steve Jean

Open access · bronzeAbstract read
In one paragraph

Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
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  4. RAB5C Increases Endothelial Release of VWF by Regulating Vesicle Trafficking.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
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  10. Rab21 recruits EEA1 and competes with Rab5 for Rabex-5 activation.Frontiers in cell and developmental biology · 2025
    Article
  11. Extracellular Vesicle MicroRNA in the Kidney.Comprehensive Physiology · 2023
    Article
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Tomas Del OlmoFaculté de Médecine et des Sciences de la Santé, Département d'Anatomie et de Biologie Cellulaire, Université de Sherbrooke, Sherbrooke, QC, Canada.
Annie LauzierFaculté de Médecine et des Sciences de la Santé, Département d'Anatomie et de Biologie Cellulaire, Université de Sherbrooke, Sherbrooke, QC, Canada.
Caroline NormandinFaculté de Médecine et des Sciences de la Santé, Département d'Anatomie et de Biologie Cellulaire, Université de Sherbrooke, Sherbrooke, QC, Canada.
Raphaëlle LarcherFaculté de Médecine et des Sciences de la Santé, Département d'Anatomie et de Biologie Cellulaire, Université de Sherbrooke, Sherbrooke, QC, Canada.
Mia LecoursFaculté de Médecine et des Sciences de la Santé, Département d'Anatomie et de Biologie Cellulaire, Université de Sherbrooke, Sherbrooke, QC, Canada.
Dominique JeanFaculté de Médecine et des Sciences de la Santé, Département d'Anatomie et de Biologie Cellulaire, Université de Sherbrooke, Sherbrooke, QC, Canada.
Louis LessardFaculté de Médecine et des Sciences de la Santé, Département d'Anatomie et de Biologie Cellulaire, Université de Sherbrooke, Sherbrooke, QC, Canada.
Florian SteinbergCenter for Biological Systems Analysis (ZBSA), Faculty of Biology, Albert Ludwigs Universitaet Freiburg, Freiburg, Germany.
François-Michel BoisvertFaculté de Médecine et des Sciences de la Santé, Département d'Anatomie et de Biologie Cellulaire, Université de Sherbrooke, Sherbrooke, QC, Canada.
Steve JeanFaculté de Médecine et des Sciences de la Santé, Département d'Anatomie et de Biologie Cellulaire, Université de Sherbrooke, Sherbrooke, QC, Canada steve.jean@usherbrooke.ca.ORCID 0000-0001-6881-5781
Université de Sherbrooke · CAUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RAB GTPases are central modulators of membrane trafficking. They are under the dynamic regulation of activating guanine exchange factors (GEFs) and inactivating GTPase-activating proteins (GAPs). Once activated, RABs recruit a large spectrum of effectors to control trafficking functions of eukaryotic cells. Multiple proteomic studies, using pull-down or yeast two-hybrid approaches, have identified a number of RAB interactors. However, due to the

Indexed as

ClathrinDNA-(Apurinic or Apyrimidinic Site) LyaseEndonucleasesEndosomesHumansMass SpectrometryMultifunctional EnzymesProtein BindingProtein Interaction MappingProtein Interaction MapsProtein Transportrab GTP-Binding ProteinsRNA, Guide, CRISPR-Cas SystemsAPEX2 protein, humanClathrinDNA-(Apurinic or Apyrimidinic Site) LyaseEndonucleasesMultifunctional EnzymesRAB21 protein, humanrab GTP-Binding ProteinsRNA, Guide, CRISPR-Cas SystemsAPEX2clathrin‐independent endocytosisRAB GTPasesretromerWASH complex

Identifiers

PMID30610016
PMCPMC6362359
OpenAlexW2907024869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.