Evidence map›Paper›PMID 30609839›Full record

ReviewMaterials (Basel, Switzerland)2019

Nanoheterostructures (NHS) and Their Applications in Nanomedicine: Focusing on In Vivo Studies.

Alessandra Quarta, Clara Piccirillo, Giacomo Mandriota, Riccardo Di Corato

Abstract readReview
In one paragraph

Review in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alessandra QuartaCNR NANOTEC-Institute of Nanotechnology, c/o Campus Ecotekne, University of Salento, Via Monteroni, 73100 Lecce, Italy. alessandra.quarta@nanotec.cnr.it.ORCID 0000-0003-1911-9864
Clara PiccirilloCNR NANOTEC-Institute of Nanotechnology, c/o Campus Ecotekne, University of Salento, Via Monteroni, 73100 Lecce, Italy. clara.piccirillo@nanotec.cnr.it.ORCID 0000-0002-6339-716X
Giacomo MandriotaDepartment of Mathematics and Physics "E. De Giorgi", University of Salento, via Arnesano, 73100 Lecce, Italy. giacomo.mandriota@unisalento.it.ORCID 0000-0002-5355-5419
Riccardo Di CoratoDepartment of Mathematics and Physics "E. De Giorgi", University of Salento, via Arnesano, 73100 Lecce, Italy. riccardo.dicorato@unisalento.it.ORCID 0000-0002-7173-6176

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inorganic nanoparticles have great potential for application in many fields, including nanomedicine. Within this class of materials, inorganic nanoheterostructures (NHS) look particularly promising as they can be formulated as the combination of different domains; this can lead to nanosystems with different functional properties, which, therefore, can perform different functions at the same time. This review reports on the latest development in the synthesis of advanced NHS for biomedicine and on the tests of their functional properties in in vivo studies. The literature discussed here focuses on the diagnostic and therapeutic applications with special emphasis on cancer. Considering the diagnostics, a description of the NHS for cancer imaging and multimodal imaging is reported; more specifically, NHS for magnetic resonance, computed tomography and luminescence imaging are considered. As for the therapeutics, NHS employed in magnetic hyperthermia or photothermal therapies are reported. Examples of NHS for cancer theranostics are also presented, emphasizing their dual usability in vivo, as imaging and therapeutic tools. Overall, NHS show a great potential for biomedicine application; further studies, however, are necessary regarding the safety associated to their use.

Indexed as

biomedicinehyperthermiaimagingin vivo testingnanoheterostructuresphotothermal therapy

Identifiers

PMID30609839
PMCPMC6337150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.