ArticleNutrients2019
Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts.
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Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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21citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Vitamin D and human health: evidence from Mendelian randomization studies.European journal of epidemiology · 2024Pooled it
- Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Pooled it
- 25-Hydroxyvitamin D levels are associated with mortality and cardiovascular events in systemic lupus erythematosus.Annals of the rheumatic diseases · 2026Article
- Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows.Endocrine reviews · 2024Article
- Prenatal vitamin D deficiency exposure leads to long-term changes in immune cell proportions.Scientific reports · 2024Article
- The Role of Intestinal Cytochrome P450s in Vitamin D Metabolism.Biomolecules · 2024Article
- Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Review
- Article
- Change of vitamin D status and all-cause mortality among Chinese older adults: a population-based cohort study.BMC geriatrics · 2022Article
- Article
- Determinants of vitamin D status in Kenyan calves.Scientific reports · 2020Article
- Vitamin D deficiency 2.0: an update on the current status worldwide.European journal of clinical nutrition · 2020Review
- Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of thyroid autoimmunity: a narrative review.Journal of endocrinological investigation · 2020Review
- Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci.American journal of human genetics · 2020Article
- Article
- Effect of 9 months of vitamin D supplementation on arterial stiffness and blood pressure in Graves' disease: a randomized clinical trial.Endocrine · 2019Article
- A Review of the Potential Benefits of Increasing Vitamin D Status in Mongolian Adults through Food Fortification and Vitamin D Supplementation.Nutrients · 2019Review
- Elite athletes as research model: vitamin D insufficiency associates with elevated central blood pressure in professional handball athletes.European journal of applied physiology · 2019Article
- Vitamin D and Atherosclerotic Cardiovascular Disease.The Journal of clinical endocrinology and metabolism · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 17 institutions in 9 countries.
Thor AspelundIcelandic Heart Association, 201 Kopavogur, Iceland. thor@hi.is.ORCID 0000-0002-7998-5433
Martin R GrüblerDepartment of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria. martin.gruebler@gmx.net.ORCID 0000-0002-1761-2914
Albert V SmithIcelandic Heart Association, 201 Kopavogur, Iceland. albertvs@umich.edu.ORCID 0000-0003-1942-5845
Elias F GudmundssonIcelandic Heart Association, 201 Kopavogur, Iceland. elias@hjarta.is.ORCID 0000-0002-7661-4872
Martin KeppelDepartment of Laboratory Medicine, Paracelsus Medical University, 5020 Salzburg, Austria. keppel.martin@gmail.com.
Mary Frances CotchDivision of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, MD 20892-1204, USA. mfc@nei.nih.gov.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD 20814, USA. tamara.b.harris@gmail.com.
Rolf JordeTromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. rolf.jorde@unn.no.
Guri GrimnesTromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. guri.grimnes@uit.no.
Ragnar JoakimsenTromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. ragnar.joakimsen@uit.no.
Henrik SchirmerTromsø Cardiovascular Research Group UNN, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. henrik.schirmer@uit.no.
Tom WilsgaardDepartment of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. tom.wilsgaard@uit.no.
Ellisiv B MathiesenBrain and Circulation Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. ellisiv.mathiesen@uit.no.
Inger NjølstadDepartment of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. inger.njolstad@uit.no.
Maja-Lisa LøchenDepartment of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway. maja-lisa.lochen@uit.no.
Winfried MärzMedical Clinic V, Mannheim Medical Faculty, University of Heidelberg, 68167 Mannheim, Germany. Winfried.Maerz@synlab.com.
Marcus E KleberMedical Clinic V, Mannheim Medical Faculty, University of Heidelberg, 68167 Mannheim, Germany. Marcus.Kleber@medma.uni-heidelberg.de.
Andreas TomaschitzDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria. andreas.tomaschitz@medunigraz.at.
Diana Grove-LaugesenDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark. jenngrov@rm.dk.ORCID 0000-0002-9681-7394
Lars RejnmarkDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, Denmark. lars.rejnmark@rm.dk.ORCID 0000-0002-2152-4247
Karin M A SwartAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health, 1081 Amsterdam, The Netherlands. k.swart@vumc.nl.
Ingeborg A BrouwerDepartment of Health Sciences, Faculty of Sciences and Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 Amsterdam, The Netherlands. ingeborg.brouwer@vu.nl.
Paul LipsDepartment of Internal Medicine, Endocrine Section, VU University Medical Center, 1081 Amsterdam, The Netherlands. P.Lips@vumc.nl.
Natasja M van SchoorAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health, 1081 Amsterdam, The Netherlands. nm.vanschoor@vumc.nl.
Christopher T SemposOffice of Dietary Supplements, National Institute of Health, Bethesda, MD 20892-7517, USA. semposch@gmail.com.
Ramón A Durazo-ArvizuDepartment of Public Health Sciences, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA. rdurazo@LUC.edu.
Zuzana ŠkrabákováCork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork T12K8AF, Ireland. zuzkani@gmail.com.ORCID 0000-0001-8216-6693
Kirsten G DowlingCork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork T12K8AF, Ireland. 115224470@umail.ucc.ie.
Kevin D CashmanCork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork T12K8AF, Ireland. K.Cashman@ucc.ie.ORCID 0000-0002-8185-1039
Mairead KielyCork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork T12K8AF, Ireland. M.Kiely@ucc.ie.ORCID 0000-0003-0973-808X
Stefan PilzDepartment of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria. stefan.pilz@chello.at.
Vilmundur GudnasonIcelandic Heart Association, 201 Kopavogur, Iceland. v.gudnason@hjarta.is.
Gudny EiriksdottirIcelandic Heart Association, 201 Kopavogur, Iceland. gudny@hjarta.is.ORCID 0000-0002-8197-0652
UiT The Arctic University of Norway · NOUniversity College Cork · IEMedical University of Graz · ATUniversity of Iceland · ISAarhus University Hospital · DKAmsterdam University Medical Centers · NLIcelandic Heart Association · ISAmsterdam UMC Location Vrije Universiteit Amsterdam · NLHeidelberg University · DELoyola University Chicago · USNational Eye Institute · USNational Institute on Aging · USOffice of Dietary Supplements · USParacelsus Medical University · ATUniversity Hospital of North Norway · NOUniversity of Bern · CHVrije Universiteit Amsterdam · NL
Funding
Age, Gene/environment Susceptibility Study In Iceland - Ocular ComponentZIAEY000401 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2009 to 2020
$3.3MDEVELOPMENT OF AN IMPROVED TACTUAL VOCODERR43DC001004 · NIDCD · INTELLIGENT HEARING SYSTEMS · PI MISKIEL, EDWARD · 1991 to 1991
–National Eye Institute ZIAEY000401National Institute on Deafness and Other Communication Disorders IAA Y2-DC_1004-02National Institutes of Health N01-AG012100Seventh Framework Programme FP7-613977-ODIN
Abstract
The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D Standardization Program. Most relevant single nucleotide polymorphisms of the genes
Indexed as
Genetic Predisposition to DiseaseMendelian Randomization AnalysisAgedAged, 80 and overCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCholestanetriol 26-MonooxygenaseCohort StudiesCytochrome P450 Family 2EuropeFemaleGene Expression RegulationHumansMaleMiddle AgedMortalityOxidoreductases Acting on CH-CH Group Donors25-hydroxyvitamin D7-dehydrocholesterol reductaseCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCholestanetriol 26-MonooxygenaseCYP2R1 protein, humanCytochrome P450 Family 2NADSYN1 protein, humanOxidoreductases Acting on CH-CH Group DonorsVitamin DcohortsIndividual Participant DataMendelian randomizationmortalitystandardized 25(OH)DVitamin D
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.