Evidence map›Paper›PMID 30609397›Full record

ArticleCell stem cell2019

Huntington Disease's Glial Progenitor Cells Hit the Pause Button in the Mouse Brain.

Nan Wang, X William Yang

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Non-Cell Autonomous and Epigenetic Mechanisms of Huntington's Disease.International journal of molecular sciences · 2021
    Review
  3. Developmental Alterations in Adult-Onset Neurodegenerative Disorders: Lessons from Polyglutamine Diseases.Movement disorders : official journal of the Movement Disorder Society · 2021
    Article
  4. Review
  5. A Critical Review of White Matter Changes in Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Nan WangCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
X William YangCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: xwyang@mednet.ucla.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

White matter abnormalities are prominent neuropathological features in Huntington's disease (HD); however, the cellular culprits are unclear. In this issue of Cell Stem Cell, Osipovitch et al. (2019) show that patient-derived glial progenitor cells fail to properly differentiate and myelinate in the mouse brain due to cell-intrinsic transcriptional defects.

Indexed as

Huntington DiseaseAnimalsBrainCell DifferentiationHumansMiceNeurogliaStem Cells

Identifiers

PMID30609397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.